Methylene Chloride

Methylene Chloride

SCHEMBL3898

ClCCl.NCO.O

nearest known ligand 0.00

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Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Methylene Chloride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methylene Chloride SCHEMBL6136710 1.00 ALDH1A1 (0.40)
Methylene Chloride SCHEMBL4632464 1.00 ALDH1A1 (0.40)
Methylene Chloride SCHEMBL5665877 1.00 ALDH1A1 (0.40)
Methylene Chloride SCHEMBL365636 0.95
Methylene Chloride SCHEMBL6270920 0.90
Water SCHEMBL691249 0.84 TSHR (0.50)
Water SCHEMBL5626996 0.84 TSHR (0.50)
Water SCHEMBL7675567 0.84 TSHR (0.50)
Water SCHEMBL116947 0.84
Water SCHEMBL6075917 0.84 TSHR (0.50)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1223 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107118219-B The method of separating-purifying gelsevirine, koumidine, koumine, gelsemine and furans koumine from elegant jessamine 湖南农业大学 2019-03-15 CN claimed
US-6432953-B1 None US disclosed
CN-118215473-A Method for manufacturing medicine with shortened production time and improved stability INB博士有限公司 2024-06-18 CN disclosed
WO-2024106780-A1 NANOPARTICLE COMPOSITION FOR DRUG DELIVERY 주식회사 삼양홀딩스 2024-05-23 WO disclosed
WO-2024096408-A1 LIPID HAVING AMIDE AND ESTER FUNCTIONAL GROUPS, AND METHOD FOR PRODUCING SAME 주식회사 삼양홀딩스 2024-05-10 WO disclosed
WO-2023230472-A1 INHIBITORS OF MOLLUSCUM CONTAGIOSUM INFECTION AND METHODS USING THE SAME THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2023-11-30 WO disclosed
US-20230310645-A1 NANOPARTICLE COMPOSITION FOR THE DELIVERY OF NUCLEIC ACID AGENTS TIBA BIOTECH LLC (US) 2023-10-05 US disclosed
EP-3262036-B1 THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF GENENTECH INC (US) 2023-09-13 EP disclosed
EP-4215182-A1 DIAMINOPYRIMIDINE P2X3 AND P2X2/3 RECEPTOR MODULATORS FOR USE IN THE TREATMENT OF COUGH Afferent Pharmaceuticals Inc. (US) 2023-07-26 EP disclosed
WO-2023085567-A1 METHOD FOR PREPARING MEDICINES, HAVING REDUCED PRODUCTION TIME AND IMPROVED STABILITY 닥터아이앤비(주) 2023-05-19 WO disclosed
US-4507311-A Imidazo[1,2-c][1,3]benzodiazepines CIBA-GEIGY CORPORATION (US) 1985-03-26 US disclosed
US-4497827-A TETRAZOLE, ACYLHYDROXYLAMINE, HYDROXYMETHYLKETONE AND AMIDE DERIVATIVES SYNTEX (U.S.A.) INC. (US) 1985-02-05 US disclosed
EP-0132351-A2 9-Anthryloxyaminoalkanes and related compounds, processes for their preparation and pharmaceutical compositions containing them SYNTEX (U.S.A.) INC. (US) 1985-01-30 EP disclosed
EP-0129207-A2 Substituted phenylalkyl(piperazinyl or homopiperazinyl)-propyl-(ureas or thioureas) Boehringer Ingelheim Pharmaceuticals Inc. (US) 1984-12-27 EP disclosed
US-4490527-A Benzo-fused heterocyclic anti-ulcer agents AMERICAN HOME PRODUCTS CORPORATION (US) 1984-12-25 US disclosed
EP-0122488-A1 Bis-(piperazinyl- or homopiperazinyl)-alkanes Boehringer Ingelheim Pharmaceuticals Inc. (US) 1984-10-24 EP disclosed
US-4460587-A ANTIPSYCHOTIC AGENTS, ANTIALLERGENS CIBA-GEIGY CORPORATION (US) 1984-07-17 US disclosed
US-4447611-A ANTISECRETORY AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1984-05-08 US disclosed
EP-0104468-A1 Arachidonic acid analogues as anti-inflammatory and antiallergic agents SYNTEX (U.S.A.) INC. (US) 1984-04-04 EP disclosed
EP-0081955-A2 Benzo-fused heterocyclic compounds AMERICAN HOME PRODUCTS CORPORATION (US) 1983-06-22 EP disclosed