Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.65 |
| ▸ | DNPH1 | O43598 | 7/20 | 0.62 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.62 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.62 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.62 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.62 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.62 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.62 |
| ▸ | LDHA | P00338 | 1/20 | 0.62 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.62 |
| ▸ | FBP1 | P09467 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.62 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.62 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1933421 | 0.92 | P2RY12 (0.67) | P2RY12DNPH1P2RY1TAS1R3TAS1R1 | |
| SCHEMBL5545796 | 0.90 | P2RY12 (0.69) | P2RY12DNPH1P2RY1TAS1R3TAS1R1 | |
| SCHEMBL8328071 | 0.90 | P2RY12 (0.64) | P2RY12DNPH1P2RY1TAS1R3TAS1R1 | |
| SCHEMBL3193571 | 0.90 | P2RY12 (0.68) | P2RY12DNPH1P2RY1TAS1R3TAS1R1 | |
| SCHEMBL8570660 | 0.89 | MARS1 (0.65) | P2RY12DNPH1P2RY1TAS1R3TAS1R1 | |
| SCHEMBL4997219 | 0.89 | P2RY12 (0.69) | P2RY12DNPH1P2RY1TAS1R3TAS1R1 | |
| SCHEMBL2990779 | 0.88 | P2RY12 (0.66) | P2RY12DNPH1P2RY1TAS1R3TAS1R1 | |
| SCHEMBL8916648 | 0.88 | P2RY12 (0.70) | P2RY12DNPH1P2RY1TAS1R3TAS1R1 | |
| SCHEMBL30208541 | 0.88 | ADORA2A (0.58) | ADORA1SMN1; SMN2QARS1 | |
| SCHEMBL2988353 | 0.86 | P2RY12 (0.68) | P2RY12DNPH1P2RY1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7527943-B2 | Compositions of orthogonal glutamyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-05-05 | — | — | US | disclosed |
| US-20070020634-A1 | Composition of orthogonal glutamyl-trna and aminoacyl-trna synthetase pairs and uses thereof | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-01-25 | — | — | US | disclosed |
| EP-1658366-A4 | COMPOSITIONS OF ORTHOGONAL GLUTAMYL-TRNA AND AMINOACYL TRNA SYNTHETASE PAIRS AND USES THEREOF | SCRIPPS RESEARCH INST (US) | 2006-08-09 | — | — | EP | disclosed |
| EP-1658366-A2 | COMPOSITIONS OF ORTHOGONAL GLUTAMYL-TRNA AND AMINOACYL TRNA SYNTHETASE PAIRS AND USES THEREOF | The Scripps Research Institute (US) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005007624-A2 | COMPOSITIONS OF ORTHOGONAL GLUTAMYL-TRNA AND AMINOACYL TRNA SYNTHETASE PAIRS AND USES THEREOF | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070020634-A1 | Composition of orthogonal glutamyl-trna and aminoacyl-trna synthetase pairs and uses thereof | AARS1, GARS1, EPRS1 | P2RY12 4727/4885DNPH1 1752/4885P2RY1 4832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.