Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 3/20 | 0.39 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5698823 | 0.84 | SMN1; SMN2 (0.41) | MAPTALDH1A1GAASMN1; SMN2L3MBTL1 | |
| SCHEMBL6472002 | 0.84 | HTR2A (0.48) | MAPTALDH1A1GAASMN1; SMN2L3MBTL1 | |
| SCHEMBL520960 | 0.83 | CKS1B (0.49) | MAPTSMN1; SMN2MEN1POLBKMT2A | |
| SCHEMBL3917775 | 0.82 | SMN1; SMN2 (0.47) | MAPTALDH1A1GAASMN1; SMN2L3MBTL1 | |
| SCHEMBL4800403 | 0.82 | CYP1A2 (0.42) | MAPTALDH1A1SMN1; SMN2L3MBTL1HRH1 | |
| SCHEMBL3916322 | 0.82 | HRH1 (0.45) | MAPTALDH1A1GAASMN1; SMN2L3MBTL1 | |
| SCHEMBL5757481 | 0.81 | LMNA (0.47) | MAPTALDH1A1GAASMN1; SMN2L3MBTL1 | |
| SCHEMBL5698822 | 0.81 | IDE (0.40) | MAPTALDH1A1GAASMN1; SMN2L3MBTL1 | |
| SCHEMBL4386582 | 0.80 | HTR6 (0.67) | MAPTALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL5758622 | 0.80 | HTT (0.44) | MAPTALDH1A1GAASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027108-A1 | HISTAMINE RECEPTOR ANTAGONISTS COMPRISING AN AZEPIN CORE | Glaxo Group Limited (GB) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007135081-A1 | HISTAMINE RECEPTOR ANTAGONISTS COMPRISING AN AZEPIN CORE | GLAXO GROUP LIMITED (GB) | 2007-11-29 | — | — | WO | disclosed |