Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5758622 | 0.91 | HTT (0.44) | LMNAMAPTKMT2AMAPK1HTR2A | |
| SCHEMBL4701379 | 0.85 | TGM2 (0.47) | LMNAMAPTHTR2AHTR6HTR1A | |
| SCHEMBL5758760 | 0.85 | HTR2A (0.48) | LMNAMAPTKMT2AHTR2AHTR6 | |
| SCHEMBL5757786 | 0.85 | LMNA (0.45) | LMNAMAPTKMT2AMAPK1HTR2A | |
| SCHEMBL4386582 | 0.83 | HTR6 (0.67) | LMNAMAPTKMT2AMAPK1HTR2A | |
| SCHEMBL3917828 | 0.81 | MAPT (0.43) | LMNAMAPTKMT2AMAPK1HTR2A | |
| SCHEMBL5698823 | 0.78 | SMN1; SMN2 (0.41) | LMNAMAPTKMT2AMAPK1ALDH1A1 | |
| SCHEMBL6472002 | 0.78 | HTR2A (0.48) | LMNAMAPTKMT2AMAPK1HTR2A | |
| SCHEMBL4699246 | 0.77 | TGM2 (0.46) | MAPTHTR2AHTR6HTR1ADRD2 | |
| SCHEMBL3917775 | 0.76 | SMN1; SMN2 (0.47) | MAPTKMT2AHTR2AHTR6HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660483-A1 | 8-(1-PIPERAZINYL)-QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005021530-A1 | 8- (1-PIPERAZINYL)- QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-03-10 | — | — | WO | disclosed |