Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5757481 | 0.91 | LMNA (0.47) | HTTLMNAALDH1A1MAPK1POLB | |
| SCHEMBL4699246 | 0.86 | TGM2 (0.46) | HTTALDH1A1POLBTSHRMAPT | |
| SCHEMBL5758760 | 0.84 | HTR2A (0.48) | HTTLMNAALDH1A1USP2TSHR | |
| SCHEMBL5757786 | 0.83 | LMNA (0.45) | HTTLMNAALDH1A1MAPK1MAPT | |
| SCHEMBL4386582 | 0.81 | HTR6 (0.67) | HTTLMNAALDH1A1MAPK1TSHR | |
| SCHEMBL3917828 | 0.80 | MAPT (0.43) | HTTLMNAALDH1A1MAPK1POLB | |
| SCHEMBL4701379 | 0.77 | TGM2 (0.47) | HTTLMNAALDH1A1TSHRMAPT | |
| SCHEMBL5698823 | 0.77 | SMN1; SMN2 (0.41) | HTTLMNAALDH1A1MAPK1TSHR | |
| SCHEMBL4701408 | 0.77 | HTR6 (0.66) | HTTALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL6472002 | 0.77 | HTR2A (0.48) | LMNAALDH1A1MAPK1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660483-A1 | 8-(1-PIPERAZINYL)-QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005021530-A1 | 8- (1-PIPERAZINYL)- QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-03-10 | — | — | WO | disclosed |