Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.50 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.50 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.50 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.50 |
| ▸ | HTR3B | O95264 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.50 |
| ▸ | NOS3 | P29474 | 4/20 | 0.48 |
| ▸ | NOS1 | P29475 | 4/20 | 0.48 |
| ▸ | NOS2 | P35228 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3921499 | 0.86 | SIGMAR1 (0.51) | MEN1KMT2ASIGMAR1ALDH1A1GLA | |
| SCHEMBL17360623 | 0.82 | SLC22A2 (0.50) | MEN1KMT2ASIGMAR1HTR3ESLC22A2 | |
| SCHEMBL11842169 | 0.81 | MEN1 (0.57) | MEN1KMT2ASIGMAR1ALDH1A1GLA | |
| SCHEMBL11842159 | 0.81 | MEN1 (0.57) | MEN1KMT2ASIGMAR1ALDH1A1GLA | |
| SCHEMBL8400927 | 0.80 | MEN1 (0.56) | MEN1KMT2ASIGMAR1ALDH1A1GLA | |
| SCHEMBL6157663 | 0.79 | NOS1 (0.54) | MEN1KMT2ASIGMAR1ALDH1A1HTR3E | |
| SCHEMBL17329339 | 0.78 | SLC22A2 (0.46) | MEN1KMT2ASIGMAR1HTR3ESLC22A2 | |
| SCHEMBL3911421 | 0.77 | ALDH1A1 (0.50) | MEN1KMT2ASIGMAR1ALDH1A1GLA | |
| SCHEMBL7562289 | 0.77 | SLC22A2 (0.44) | MEN1KMT2ASIGMAR1HTR3ESLC22A2 | |
| SCHEMBL6721400 | 0.77 | SIGMAR1 (0.72) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251948-B1 | Tri-and tetra-substituted guanidines and their use as excitatory amino acid antagonists | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON | 2001-06-26 | — | — | US | claimed |
| EP-2026754-A2 | LIGHTENING AND/OR COLOURING AGENT COMPRISING CYCLIC UREA DERIVATIVES | Henkel AG & Co. KGaA (DE) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007137676-A2 | LIGHTENING AND/OR COLOURING AGENT COMPRISING CYCLIC UREA DERIVATIVES | HENKEL AG & CO. KGAA (DE) | 2007-12-06 | — | — | WO | disclosed |