SCHEMBL3923262

SCHEMBL3923262

C[Si](CCCCl)(Oc1ccccc1)Oc1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNA3 P22001 1/20 0.40
LTA4H P09960 3/20 0.36
HTR1B P28222 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
DRD2 P14416 2/20 0.33
DRD3 P35462 2/20 0.33
KCNH2 Q12809 2/20 0.33
RECQL P46063 1/20 0.33
SLC22A2 O15244 1/20 0.33
SLC22A1 O15245 1/20 0.33
SLC22A3 O75751 1/20 0.33
ALDH1A1 P00352 1/20 0.33
ESR1 P03372 1/20 0.33
CHRM2 P08172 1/20 0.33
HTR1A P08908 1/20 0.33
ADRA2A P08913 1/20 0.33
ADORA3 P0DMS8 1/20 0.33
CHRM1 P11229 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL704371 0.88 KCNA3 (0.41) KCNA3LTA4HHTR1BL3MBTL1DRD2
SCHEMBL705384 0.88 KCNA3 (0.41) KCNA3LTA4HHTR1BL3MBTL1DRD2
SCHEMBL3923699 0.85 KCNA3 (0.40) KCNA3LTA4HHTR1BL3MBTL1DRD2
SCHEMBL705837 0.83 CA4 (0.42) KCNA3LTA4HHTR1BL3MBTL1KCNH2
SCHEMBL1608982 0.82 LTA4H (0.46) KCNA3LTA4HDRD2DRD3KCNH2
SCHEMBL3917624 0.81 KCNA3 (0.35) KCNA3LTA4HHTR1BL3MBTL1KCNH2
SCHEMBL3350911 0.81 HDAC3 (0.46) KCNA3LTA4HHTR1BL3MBTL1RECQL
SCHEMBL3815414 0.81 TAAR1 (0.41) KCNA3LTA4HKCNH2HTR2AHRH1
SCHEMBL3923803 0.80 KCNA3 (0.43) KCNA3LTA4HHTR1BL3MBTL1DRD2
SCHEMBL3924741 0.79 LTA4H (0.42) KCNA3LTA4HRECQLALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7619108-B2 Process for preparing unsaturated organosilicon compounds WACKER CHEMIE AG (DE) 2009-11-17 US disclosed
EP-1954701-B1 PROCESS FOR PREPARING UNSATURATED ORGANOSILICON COMPOUNDS WACKER CHEMIE AG (DE) 2009-03-18 EP disclosed
US-20080293958-A1 Process for Preparing Unsaturated Organosilicon Compounds WACKER CHEMIE AG (DE) 2008-11-27 US disclosed
US-6815554-B2 REACTING A HALOALKYLSILANE WITH A SALT OF AN UNSATURATED CARBOXYLIC ACID IN THE PRESENCE OF A PHASE TRANSFER CATALYST; BONDING AGENTS WACKER-CHEMIE GMBH (DE) 2004-11-09 US disclosed
US-20020151736-A1 PROCESS FOR PREPARING UNSATURATED ORGANOSILICON COMPOUNDS WACKER-CHEMIE GMBH (DE) 2002-10-17 US disclosed