Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL204814 | 0.87 | LMNA (0.48) | MAPTPOLBPKMLMNAKDM4E | |
| SCHEMBL23601757 | 0.77 | ALOX5 (0.46) | MAPTLMNAKDM4ECYP3A4KMT2A | |
| SCHEMBL203680 | 0.77 | ALDH1A1 (0.43) | MAPTPOLBPKMLMNAKDM4E | |
| SCHEMBL25612185 | 0.76 | LMNA (0.39) | MAPTPOLBPKMLMNAKDM4E | |
| SCHEMBL205239 | 0.75 | CA2 (0.45) | MAPTPOLBPKMLMNAKDM4E | |
| SCHEMBL27788647 | 0.75 | LMNA (0.38) | MAPTPOLBPKMLMNAKDM4E | |
| SCHEMBL6364662 | 0.74 | LMNA (0.52) | MAPTPOLBPKMLMNAKDM4E | |
| SCHEMBL3688841 | 0.72 | LMNA (0.50) | MAPTPOLBPKMLMNAKDM4E | |
| SCHEMBL23809728 | 0.72 | BACE1 (0.52) | MAPTPOLBPKMLMNAKDM4E | |
| SCHEMBL1513505 | 0.72 | ACHE (0.56) | MAPTPOLBPKMLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041123-A2 | FUSED CYCLIC COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008001931-A2 | FUSED CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-01-03 | — | — | WO | disclosed |