SCHEMBL23601757

SCHEMBL23601757

COc1cc(OC(C)=O)cc(C)c1Br

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 2/20 0.46
KDM4E B2RXH2 4/20 0.43
TSHR P16473 2/20 0.43
GLA P06280 2/20 0.43
GAA P10253 2/20 0.43
ALDH1A1 P00352 2/20 0.43
MAPT P10636 2/20 0.43
HSD17B10 Q99714 2/20 0.43
TNFSF11 O14788 1/20 0.43
CASP1 P29466 1/20 0.43
CASP7 P55210 1/20 0.43
ELANE P08246 2/20 0.41
TUBB4A P04350 2/20 0.41
TUBB P07437 2/20 0.41
TUBA3C P0DPH7 2/20 0.41
TUBA1B P68363 2/20 0.41
TUBA4A P68366 2/20 0.41
TUBB4B P68371 2/20 0.41
TUBB3 Q13509 2/20 0.41
TUBB2A Q13885 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL204814 0.85 LMNA (0.48) KDM4ETSHRGLAGAAALDH1A1
SCHEMBL16521510 0.82 ALOX5 (0.48) ALOX5KDM4ETSHRGLAGAA
SCHEMBL3146133 0.79 NQO2 (0.44) KDM4EGAAALDH1A1MAPTHSD17B10
SCHEMBL28917334 0.79 ALOX5 (0.43) ALOX5KDM4ETSHRGLAGAA
SCHEMBL3925908 0.77 MAPT (0.42) KDM4ETSHRGLAGAAALDH1A1
SCHEMBL203680 0.76 ALDH1A1 (0.43) ALOX5KDM4ETSHRGLAGAA
SCHEMBL15266000 0.76 ALOX5 (0.64) ALOX5KDM4ETSHRGAAALDH1A1
SCHEMBL736176 0.76 TUBB4A (0.63) ALOX5KDM4EGAAALDH1A1MAPT
SCHEMBL7041914 0.76 LMNA (0.59) ALOX5KDM4ETSHRTNFSF11ELANE
SCHEMBL26009120 0.75 ACHE (0.57) KDM4EGLAGAAALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230159421-A1 SUBSTITUTED HYDROXYSTILBENE COMPOUNDS AND DERIVATIVES SYNTHESIS AND USES THEREOF Kynan Duke IP, LLC (US) 2023-05-25 US disclosed
CN-115485259-A Substituted hydroxystilbene compounds and derivatives, synthesis and use thereof 凯楠公爵IP有限责任公司 2022-12-16 CN disclosed
WO-2021127743-A1 SUBSTITUTED HYDROXYSTILBENE COMPOUNDS AND DERIVATIVES SYNTHESIS AND USES THEREOF Kynan Duke IP, LLC (US) 2021-07-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230159421-A1 SUBSTITUTED HYDROXYSTILBENE COMPOUNDS AND DERIVATIVES SYNTHESIS AND USES THEREOF CYP8B1, HSD11B1, HSD11B2 ALOX5 161/4885KDM4E 3324/4885TSHR 2215/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.