SCHEMBL392678

SCHEMBL392678

O=C(O)C12CC3CC(CC1C3)C2

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.40
CYP2C9 P11712 1/20 0.40
EPHX2 P34913 2/20 0.39
EPHX1 P07099 1/20 0.39
P2RX7 Q99572 1/20 0.39
CNR2 P34972 1/20 0.39
HSD11B1 P28845 4/20 0.36
GAA P10253 1/20 0.36
SLC1A2 P43004 1/20 0.35
ALDH1A1 P00352 2/20 0.34
TSHR P16473 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL838918 1.00 THRB (0.40) THRBCYP2C9EPHX2EPHX1P2RX7
SCHEMBL23453794 1.00 THRB (0.40) THRBCYP2C9EPHX2EPHX1P2RX7
SCHEMBL19912146 0.81 HSD11B1 (0.35) THRBCYP2C9EPHX2EPHX1HSD11B1
SCHEMBL927164 0.80 P2RX7 (0.42) THRBCYP2C9EPHX2EPHX1P2RX7
SCHEMBL3242289 0.78 HSD11B1 (0.39) THRBCYP2C9EPHX2EPHX1P2RX7
SCHEMBL29837434 0.78 HSD11B1 (0.39) THRBCYP2C9EPHX2EPHX1P2RX7
SCHEMBL1326077 0.78 ALDH1A1 (0.42) THRBCYP2C9EPHX2EPHX1P2RX7
SCHEMBL20194631 0.78 CNR2 (0.41) THRBCYP2C9EPHX2EPHX1P2RX7
SCHEMBL6280421 0.78 MEN1 (0.42) P2RX7CNR2ALDH1A1TSHR
SCHEMBL9679160 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 204 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4661890-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS Purdue Research Foundation (US) 2025-12-17 EP claimed
WO-2024167565-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS PURDUE RESEARCH FOUNDATION (US) 2024-08-15 WO claimed
US-10072043-B2 Inhibitors of protein tyrosine phosphatases INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2018-09-11 US claimed
US-20160176922-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES Indiana University Research and Technology Corpora tion (US) 2016-06-23 US claimed
US-9217012-B2 Inhibitors of protein tyrosine phosphatases INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2015-12-22 US claimed
US-20120088720-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATI (US) 2012-04-12 US claimed
WO-2010118241-A2 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) 2010-10-14 WO claimed
US-7732625-B2 Colorant compounds XEROX CORPORATION (US) 2010-06-08 US claimed
US-7311767-B2 Forming a salt of a liquid phase change ink carrier of stearyl stearamide, an amine substituted Xanthene, acridine, anthracene or thioxanthene chromogen, and a metal salt capable of forming a compound with two chromogens XEROX CORPORATION (US) 2007-12-25 US claimed
US-7033424-B2 Phase change inks XEROX CORPORATION (US) 2006-04-25 US claimed
US-20060021546-A1 Processes for preparing phase change inks XEROX CORPORATION 2006-02-02 US claimed
US-20060020141-A1 Metallized dye XEROX CORPORATION 2006-01-26 US claimed
US-20060016369-A1 PHASE CHANGE INKS XEROX CORPORATION 2006-01-26 US claimed
US-6946025-B2 Process for preparing tetra-amide compounds XEROX CORPORATION (US) 2005-09-20 US claimed
US-20050090690-A1 Process for preparing tetra-amide compounds XEROX CORPORATION 2005-04-28 US claimed
US-6797745-B1 Hot melt inks containing styrene or terpene polymers XEROX CORPORATION 2004-09-28 US claimed
US-12551555-B2 Compositions and methods for potentiating immune activity KUMQUAT BIOSCIENCES INC. (US) 2026-02-17 US disclosed
EP-4661890-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS Purdue Research Foundation (US) 2025-12-17 EP disclosed
EP-0343961-A2 Aryl- and heteroaryl piperazinyl carboxamides having central nervous system activity AMERICAN HOME PRODUCTS CORPORATION (US) 1989-11-29 EP disclosed
US-4873331-A ANTIDEPRESSANTS, ANXIOLYTIC AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1989-10-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10072043-B2 Inhibitors of protein tyrosine phosphatases PTPRCAP, PTPRF, PTPRS THRB 2002/4885CYP2C9 3484/4885EPHX2 2281/4885
US-12551555-B2 Compositions and methods for potentiating immune activity PTPRCAP, PTPN2, PTPRC THRB 293/4885CYP2C9 3216/4885EPHX2 2777/4885
US-20160176922-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES PTPRCAP, PTPRF, PTPRS THRB 2002/4885CYP2C9 3484/4885EPHX2 2281/4885
US-20060020141-A1 Metallized dye CDYL, CDY1; CDY1B, CDYL2 THRB 3379/4885CYP2C9 1139/4885EPHX2 1631/4885
US-20050090690-A1 Process for preparing tetra-amide compounds TAF9, TAF5, TAF1 THRB 3311/4885CYP2C9 330/4885EPHX2 1237/4885
US-20120088720-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES PTPRCAP, PTPRF, PTPRS THRB 2002/4885CYP2C9 3484/4885EPHX2 2281/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.