Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | RGS12 | O14924 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3930964 | 0.86 | ALDH1A1 (0.45) | TSHRKDM4EPOLBGAAMAPT | |
| SCHEMBL3936709 | 0.79 | CCR5 (0.52) | SMN1; SMN2 | |
| SCHEMBL3047472 | 0.72 | SMN1; SMN2 (0.47) | KDM4EPOLBGAATDP1LMNA | |
| SCHEMBL6707987 | 0.71 | GRM2 (0.47) | LMNAHSD17B10CA2GRM2SMN1; SMN2 | |
| SCHEMBL10825727 | 0.70 | GAA (0.70) | TSHRKDM4EPOLBGAANFKB1 | |
| SCHEMBL220097 | 0.70 | SIGMAR1 (0.62) | TSHRGAATDP1HIF1AALDH1A1 | |
| SCHEMBL4751222 | 0.68 | SMN1; SMN2 (0.58) | KDM4EPOLBTDP1LMNABLM | |
| SCHEMBL2988721 | 0.68 | KMT2A (0.51) | TSHRKDM4EPOLBGAANFKB1 | |
| SCHEMBL12125341 | 0.67 | HPGD (0.66) | TSHRKDM4EPOLBGAANFKB1 | |
| SCHEMBL166595 | 0.67 | SMN1; SMN2 (0.52) | TSHRPOLBHSD17B10ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |