Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3929448 | 0.86 | TSHR (0.43) | ALDH1A1GAAGFERPDCD1CD274 | |
| SCHEMBL3932131 | 0.81 | CCR5 (0.51) | SMN1; SMN2 | |
| SCHEMBL3937537 | 0.77 | ALDH1A1 (0.49) | ALDH1A1GAAGFERSMN1; SMN2KDM4E | |
| SCHEMBL14367070 | 0.77 | ALDH1A1 (0.49) | ALDH1A1GAAGFERSMN1; SMN2KDM4E | |
| SCHEMBL8145260 | 0.73 | ALDH1A1 (0.68) | ALDH1A1GAAGFERSMN1; SMN2KDM4E | |
| SCHEMBL3932024 | 0.72 | VEGFA (0.51) | ALDH1A1GAAGFERSMN1; SMN2KDM4E | |
| SCHEMBL14424032 | 0.71 | ACHE (0.53) | ALDH1A1GAAGFERHSP90AB1TSHR | |
| SCHEMBL12552396 | 0.71 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2KDM4EPOLBTSHR | |
| SCHEMBL22273409 | 0.70 | ALDH1A1 (0.67) | ALDH1A1GAAGFERKDM4EHSD17B10 | |
| SCHEMBL25205014 | 0.69 | HSD17B10 (0.53) | ALDH1A1GAASMN1; SMN2POLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |