Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 9/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3921099 | 0.79 | CRHR1 (0.55) | SMPD3PI4KBCRHR1CRHR2 | |
| SCHEMBL4787114 | 0.77 | TLR8 (0.38) | SMPD3CRHR1CRHR2 | |
| SCHEMBL4689862 | 0.76 | CRHR1 (0.45) | SMPD3CRHR1 | |
| SCHEMBL4690582 | 0.71 | CRHR1 (0.53) | CRHR1CRHR2 | |
| SCHEMBL4693477 | 0.71 | CRHR1 (0.67) | CRHR1CRHR2 | |
| SCHEMBL4693619 | 0.71 | CRHR1 (0.67) | CRHR1CRHR2 | |
| SCHEMBL4694319 | 0.70 | CRHR1 (0.37) | CRHR1CRHR2 | |
| SCHEMBL4694546 | 0.70 | CRHR1 (0.39) | CRHR1CRHR2 | |
| SCHEMBL4695462 | 0.69 | ADRA2A (0.43) | CRHR1ALOX5 | |
| SCHEMBL3920616 | 0.69 | CRHR1 (0.57) | SMPD3PI4KBCRHR1CRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869049-B1 | IMIDAZOPYRIDAZINE COMPOUNDS | LILLY CO ELI (US) | 2009-03-04 | — | — | EP | disclosed |