Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | CDC25B | P30305 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8723810 | 0.92 | ALDH1A1 (0.42) | ALDH1A1TDP1CYP3A4HPGDTSHR | |
| SCHEMBL5425959 | 0.85 | ALDH1A1 (0.33) | ALDH1A1TDP1CYP3A4HPGDTSHR | |
| SCHEMBL14596146 | 0.80 | CYP3A4 (0.39) | TDP1CYP3A4KMT2AMEN1PARP1 | |
| SCHEMBL3425344 | 0.79 | CYP3A4 (0.38) | TDP1CYP3A4DRD1 | |
| SCHEMBL5425957 | 0.78 | LOXL2 (0.35) | TDP1CYP3A4DRD1 | |
| SCHEMBL6053500 | 0.76 | ALDH1A1 (0.38) | ALDH1A1TDP1CYP3A4HPGDTSHR | |
| SCHEMBL18319527 | 0.76 | ALDH1A1 (0.38) | ALDH1A1TDP1CYP3A4HPGDTSHR | |
| SCHEMBL14596133 | 0.75 | CA1 (0.38) | ALDH1A1TDP1CYP3A4TSHRKMT2A | |
| SCHEMBL5107 | 0.73 | ALDH1A1 (0.44) | ALDH1A1TDP1CYP3A4TSHRHSD17B10 | |
| SCHEMBL146878 | 0.73 | ALDH1A1 (0.44) | ALDH1A1TDP1CYP3A4TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990318-A | Soluble polyester-supported chiral phosphines | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 1999-11-23 | — | — | US | claimed |
| EP-0258967-B2 | Process for producing optically active alcohols | TAKASAGO PERFUMERY CO LTD (JP) | 1996-08-21 | — | — | EP | claimed |
| EP-0272787-B1 | CATALYTIC PRODUCTION OF OPTICALLY ACTIVE CARBOXYLIC ACID | Takasago International Corporation (JP) | 1992-05-06 | — | — | EP | claimed |
| US-4962230-A | RUTHENIUM-OPTICALLY ACTIVE PHOSPHINE COMPLEX HYDROGENATION CATALYST | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1990-10-09 | — | — | US | claimed |
| EP-0272787-A2 | Catalytic production of optically active carboxylic acid | Takasago International Corporation (JP) | 1988-06-29 | — | — | EP | claimed |
| JP-62178594-A | — | — | None | — | — | JP | disclosed |
| EP-1409493-B1 | METHOD FOR PRODUCING NON-CHIRAL ORGANIC COMPOUNDS CONTAINING OPTICALLY ACTIVE HYDROXY GROUPS | ARLT DIETER (DE) | 2009-04-15 | — | — | EP | disclosed |
| US-6787676-B2 | REACTING A CARBONYL COMPOUND WITH HYDROGEN IN THE PRESENCE OF A CATALYST, A BASE AND OPTIONALLY A DIAMINE, WHERE THE CATALYST IS A SUPPORT-BONDED RUTHENIUM(II) COMPLEX BISPHOSPHINE LIGAND AND A DIAMINE LIGAND | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 2004-09-07 | — | — | US | disclosed |
| US-20020111515-A1 | Reacting a carbonyl compound with hydrogen in the presence of a catalyst, a base and optionally a diamine, where the catalyst is a support-bonded ruthenium(II) complex bisphosphine ligand and a diamine ligand | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 2002-08-15 | — | — | US | disclosed |
| EP-0855390-B1 | A process for producing optically active pyrrolidine derivatives | TAKASAGO PERFUMERY CO LTD (JP) | 2001-10-04 | — | — | EP | disclosed |
| US-5942629-A | HYDROGENATING 3-ACETYL-1-BENZYL-2-PYRROLIDINONE IN PRESENCE OF A COMPLEX FORMED FROM BIDENTATE PHOSPHINE AND RUTHENIUM CATALYST TO PRODUCE INTERMEDIATE, REDUCING THE INTERMEDIATE, MESYLATING OR TOSYLATING THE PRODUCT, FINALLY METHYLAMINATING | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1999-08-24 | — | — | US | disclosed |
| US-5587510-A | ASYMMETRICAL HYDROGENATION USING RUTHENIUM-PHOPSHINE COMPLEX AS CATALYSTS | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1996-12-24 | — | — | US | disclosed |
| EP-0258967-B2 | Process for producing optically active alcohols | TAKASAGO PERFUMERY CO LTD (JP) | 1996-08-21 | — | — | EP | disclosed |
| US-5204460-A | Reacting azetidinone compound with acetic acid and oxidizing agent in the presence of ruthenium catalyst | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1993-04-20 | — | — | US | disclosed |
| EP-0272787-B1 | CATALYTIC PRODUCTION OF OPTICALLY ACTIVE CARBOXYLIC ACID | Takasago International Corporation (JP) | 1992-05-06 | — | — | EP | disclosed |
| EP-0258967-A2 | Process for producing optically active alcohols | Takasago Perfumery Co., Ltd. (JP) | 1988-03-09 | — | — | EP | disclosed |
| US-4705895-A | METAL COMPLEXES AS ASYMMETRIC SYNTHESES | TAKASAGO PERFUMERY CO., LTD. (JP) | 1987-11-10 | — | — | US | disclosed |
| EP-0235450-A1 | Phosphine compounds for complex catalysts for asymmetric syntheses | Takasago Perfumery Co., Ltd. (JP) | 1987-09-09 | — | — | EP | disclosed |
| JP-S62178594-A | NOVEL PHOSPHINE COMPOUND | TAKASAGO CORP | 1987-08-05 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020111515-A1 | Reacting a carbonyl compound with hydrogen in the presence of a catalyst, a base and optionally a diamine, where the catalyst is a support-bonded ruthenium(II) complex bisphosphine ligand and a diamine ligand | PDK1, ADH1A, HRH3 | ALDH1A1 218/4885TDP1 3989/4885CYP3A4 2449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.