Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 3/20 | 0.41 |
| ▸ | MC5R | P33032 | 3/20 | 0.41 |
| ▸ | MC3R | P41968 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4200462 | 0.86 | HTR2A (0.43) | DRD2HTR2AHTR7KCNH2MC4R | |
| SCHEMBL3944224 | 0.75 | DRD2 (0.48) | DRD2HTR2AHTR1AHTR7KCNH2 | |
| SCHEMBL27969842 | 0.74 | OPRD1 (0.57) | DRD2KCNH2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3942488 | 0.74 | RAB9A (0.49) | MC4RMC5RMC3RKMT2AMEN1 | |
| SCHEMBL3943966 | 0.73 | RAB9A (0.43) | KMT2AMEN1SMN1; SMN2CCR5ALDH1A1 | |
| SCHEMBL3943143 | 0.72 | RAB9A (0.51) | KMT2AMEN1SMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL28095554 | 0.72 | MEN1 (0.59) | DRD2HTR2AHTR1AKCNH2KMT2A | |
| SCHEMBL4200459 | 0.71 | RAB9A (0.43) | DRD2HTR2AHTR7KMT2AMEN1 | |
| SCHEMBL3129331 | 0.68 | MEN1 (0.42) | DRD2HTR2AHTR7KCNH2KMT2A | |
| Trifluoroacetic Acid SCHEMBL27969983 | 0.68 | OPRM1 (0.50) | DRD2HTR2AHTR1AKCNH2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009019508-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2009-02-12 | — | — | WO | claimed |
| WO-2009019508-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2009-02-12 | — | — | WO | disclosed |