Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | STAT6 | P42226 | 2/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.34 |
| ▸ | DRD2 | P14416 | 4/20 | 0.34 |
| ▸ | DRD1 | P21728 | 4/20 | 0.34 |
| ▸ | DRD4 | P21917 | 4/20 | 0.34 |
| ▸ | DRD3 | P35462 | 4/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3952000 | 0.90 | SLC16A3 (0.40) | CASRPTGS2RAB9ANPSR1ATM | |
| SCHEMBL3942976 | 0.79 | CASR (0.41) | CASRGAAMAPT | |
| SCHEMBL3945243 | 0.79 | FYN (0.39) | RAB9AATMKDM4EHSD17B10TDP1 | |
| SCHEMBL3943937 | 0.77 | NPY5R (0.47) | CASRPTGS2RAB9ANPSR1ATM | |
| SCHEMBL3950139 | 0.76 | CASR (0.37) | CCNE2CCNE1CDK2CASRACACB | |
| SCHEMBL3945147 | 0.76 | TSPO (0.37) | CCNE2CCNE1CDK2CASRNPSR1 | |
| SCHEMBL1386304 | 0.76 | SLC16A3 (0.41) | CASRPTGS2RAB9ANPSR1ATM | |
| SCHEMBL3942465 | 0.76 | CASR (0.41) | CASRACACBKDM4ESMN1; SMN2 | |
| SCHEMBL3947316 | 0.75 | CASR (0.41) | CASR | |
| SCHEMBL3946482 | 0.75 | ALOX5 (0.39) | RAB9ANPSR1ADRB2DRD1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718632-B1 | PYRIMIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SANOFI AVENTIS (FR) | 2009-04-22 | — | — | EP | claimed |