SCHEMBL394514

SCHEMBL394514

FC(F)(F)c1cn[c]c(Cl)c1

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.38
SMN1; SMN2 Q16637 3/20 0.36
POLB P06746 2/20 0.36
PLAU P00749 1/20 0.36
KDM4E B2RXH2 1/20 0.36
HTT P42858 3/20 0.34
GAA P10253 2/20 0.34
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
NPC1 O15118 2/20 0.33
MAPK1 P28482 2/20 0.33
RAB9A P51151 2/20 0.33
MAPT P10636 2/20 0.33
LMNA P02545 1/20 0.33
GLA P06280 1/20 0.33
HPGD P15428 1/20 0.33
NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1035626 0.80 TSHR (0.33)
SCHEMBL403256 0.76 ALDH1A1 (0.32) ALDH1A1SMN1; SMN2POLBPLAUKDM4E
SCHEMBL2120862 0.76 ALDH1A1 (0.32) ALDH1A1SMN1; SMN2POLBPLAUKDM4E
SCHEMBL3709448 0.75 CYP11B2 (0.33)
SCHEMBL944873 0.74 ALDH1A1 (0.31) ALDH1A1
SCHEMBL20554214 0.74 ALDH1A1 (0.31) ALDH1A1
SCHEMBL1034476 0.74 AGBL2 (0.36) ALDH1A1
SCHEMBL2176668 0.71
SCHEMBL2177580 0.71 RAB9A (0.32) SMN1; SMN2POLBKDM4ENPC1RAB9A
SCHEMBL5887864 0.70 KIF20B (0.44) ALDH1A1SMN1; SMN2POLBKDM4EHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1386 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114621209-B 1,2, 3-Thiadiazole acetonitrile derivatives, and preparation method and application thereof 南开大学 2024-06-14 CN claimed
CN-118164921-A Propyl phenoxypropionate compound, preparation method thereof and application thereof as herbicide 山东德瑞克化工科技有限公司 2024-06-11 CN claimed
US-20230131260-A1 SUBSTITUTED THIOPHENYL URACILS, SALTS THEREOF AND THE USE THEREOF AS HERBICIDAL AGENTS SYNGENTA CROP PROTECTION AG (CH) 2023-04-27 US claimed
CN-113354646-B 8-aryloxy alkoxy substituted xanthine derivative and preparation method and application thereof 南开大学 2022-11-15 CN claimed
CN-114213403-B 1,2,4-oxadiazole-5-formamide derivative and preparation method and application thereof 贵州大学 2022-10-25 CN claimed
CN-114621209-A 1,2, 3-thiadiazole acetonitrile derivatives, and preparation method and application thereof 南开大学 2022-06-14 CN claimed
CN-114213403-A 1,2, 4-oxadiazole-5-formamide derivatives and preparation method and application thereof 贵州大学 2022-03-22 CN claimed
US-11274083-B2 Substituted thiophenyl uracils, salts thereof and the use thereof as herbicidal agents SYNGENTA CROP PROTECTION AG (CH) 2022-03-15 US claimed
EP-3728235-B1 SUBSTITUTED THIOPHENYLURACILS , THEIR SALTS AND USE OF SAID COMPOUNDS AS HERBICIDAL AGENTS SYNGENTA CROP PROTECTION AG (CH) 2022-02-09 EP claimed
EP-3728237-B1 SUBSTITUTED THIOPHENYLURACILS , THEIR SALTS AND USE OF SAID COMPOUNDS AS HERBICIDAL AGENTS SYNGENTA CROP PROTECTION AG (CH) 2022-02-09 EP claimed
EP-0317259-A2 Heterocyclic insecticides ICI AMERICAS INC. (US) 1989-05-24 EP claimed
EP-0270683-A1 ARYLOXYUREAS, PROCESS FOR THEIR PREPARATION, AND THEIR USE MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1988-06-15 EP claimed
US-4601748-A 2-phenoxy propionic acid derivatives of pentite, process for the production of these compounds as well as compositions containing the same having herbicidal effectiveness SCHERING AKTIENGESELLSCHAFT (DE) 1986-07-22 US claimed
EP-0025773-B1 ALKYLCARBOXYLIC ACID DERIVATIVES THAT CONTAIN SULPHUR AND THAT SHOW A HERBICIDAL AND PLANT GROWTH CONTROLLING ACTIVITY, THEIR PREPARATION AND USE CIBA-GEIGY AG (CH) 1984-08-01 EP claimed
EP-0029001-B1 ALPHA-PHENOXY-PROPIONYL AZOLES, THEIR PREPARATION, HERBICIDAL AGENTS CONTAINING THEM AND THEIR USE CIBA-GEIGY AG (CH) 1984-03-21 EP claimed
US-4311513-A Herbicidal α-phenoxypropionylazoles, compositions containing them, and method of use thereof CIBA-GEIGY CORPORATION (US) 1982-01-19 US claimed
US-4311514-A Sulfur-containing alkanecarboxylic acid derivatives with herbicidal and plant growth-regulating action, production thereof and method of use CIBA-GEIGY CORPORATION (US) 1982-01-19 US claimed
EP-0025773-A1 Alkylcarboxylic acid derivatives that contain sulphur and that show a herbicidal and plant growth controlling activity, their preparation and use CIBA-GEIGY AG (CH) 1981-03-25 EP claimed
US-4246419-A SULFONAMIDE DERIVATIVES IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1981-01-20 US claimed
EP-0003648-A2 4-Aryloxy-substituted phenoxypropionamide derivatives useful as herbicides, compositions containing them, and processes for making them IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1979-08-22 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11274083-B2 Substituted thiophenyl uracils, salts thereof and the use thereof as herbicidal agents UNG, TYMP, TYMS ALDH1A1 133/4885SMN1; SMN2 4822/4885POLB 750/4885
US-20230131260-A1 SUBSTITUTED THIOPHENYL URACILS, SALTS THEREOF AND THE USE THEREOF AS HERBICIDAL AGENTS UNG, TYMP, TYMS ALDH1A1 170/4885SMN1; SMN2 4823/4885POLB 758/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.