Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 13/20 | 0.70 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8648348 | 0.82 | SLC6A9 (0.67) | HTR7SLC6A9HRH3 | |
| SCHEMBL8553908 | 0.81 | HTR7 (1.00) | HTR7SLC6A9HRH3HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL8593597 | 0.80 | HTR7 (0.98) | HTR7SLC6A9HRH3HTR1ADRD2 | |
| SCHEMBL14382102 | 0.78 | SLC6A9 (1.00) | HTR7SLC6A9 | |
| SCHEMBL10812304 | 0.78 | SLC6A9 (0.60) | HTR7SLC6A9 | |
| SCHEMBL14382140 | 0.78 | SLC6A9 (1.00) | HTR7SLC6A9 | |
| SCHEMBL4456849 | 0.73 | HTR7 (0.50) | HTR7DRD2HTR1DHTR2AHTR2C | |
| SCHEMBL3945353 | 0.72 | HTR7 (0.49) | HTR7HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL20025843 | 0.71 | SLC1A3 (0.55) | SLC6A9 | |
| SCHEMBL12132457 | 0.71 | KDM4E (0.56) | SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883613-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-16 | — | — | EP | disclosed |
| WO-1997029097-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-14 | — | — | WO | disclosed |