Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 14/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3945353 | 0.83 | HTR7 (0.49) | HTR7HTR2AHTR2CSIGMAR1DRD2 | |
| SCHEMBL8643575 | 0.73 | HTR7 (0.70) | HTR7HTR2AHTR2CDRD2HTR1D | |
| SCHEMBL14375364 | 0.69 | SIGMAR1 (0.68) | SIGMAR1ACHE | |
| SCHEMBL2729765 | 0.68 | HTR7 (0.74) | HTR7HTR2AHTR2CSIGMAR1DRD2 | |
| SCHEMBL13347712 | 0.66 | ACHE (0.70) | DRD2DRD3ACHESMN1; SMN2 | |
| SCHEMBL4456846 | 0.66 | HTR7 (0.58) | HTR7SIGMAR1DRD2HTR1DDRD3 | |
| SCHEMBL8557028 | 0.66 | CARM1 (0.55) | HTR7SIGMAR1DRD2HTR1DDRD3 | |
| SCHEMBL8557026 | 0.66 | CARM1 (0.55) | HTR7SIGMAR1DRD2HTR1DDRD3 | |
| SCHEMBL13469360 | 0.65 | L3MBTL1 (0.53) | SMN1; SMN2 | |
| SCHEMBL8552181 | 0.65 | HTR7 (0.77) | HTR7HTR2AHTR2CDRD2HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2052251-A1 | COMBINATION 5-HT7 RECEPTOR ANTAGONIST AND SEROTONIN REUPTAKE INHIBITOR THERAPY | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008013556-A1 | COMBINATION 5-HT7 RECEPTOR ANTAGONIST AND SEROTONIN REUPTAKE INHIBITOR THERAPY | JANSSEN PHARMACEUTICAL N.V. (BE) | 2008-01-31 | — | — | WO | disclosed |