Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.45 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.45 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | ALB | P02768 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | RARB | P10826 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.45 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.45 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL348322 | 0.84 | HPGD (0.52) | LMNAPTGS2PTGS1CXCR1CXCR2 | |
| SCHEMBL11450473 | 0.83 | LMNA (0.50) | LMNAPTGS2PTGS1CYP2C9AKR1C3 | |
| SCHEMBL31240124 | 0.82 | PTGS2 (0.65) | LMNAPTGS2PTGS1CYP2C9AKR1C3 | |
| SCHEMBL16659374 | 0.77 | ALOX5 (0.42) | LMNAPTGS2PTGS1CYP2C9AKR1C3 | |
| SCHEMBL15442422 | 0.72 | ALDH1A1 (0.47) | TSHR | |
| SCHEMBL28857232 | 0.72 | ACHE (0.54) | LMNAACACBACACAPLA2G10PLA2G2A | |
| SCHEMBL10515119 | 0.72 | CALM1 (0.52) | LMNAACACBACACAPLA2G10PLA2G2A | |
| SCHEMBL15443310 | 0.72 | ALDH1A1 (0.51) | TSHR | |
| SCHEMBL28116999 | 0.72 | LMNA (0.46) | LMNATSHRACACBACACAPLA2G10 | |
| SCHEMBL4841473 | 0.72 | CALM1 (0.57) | LMNAEPHX1CALM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080382-B1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS | ALCON INC (CH) | 2009-07-08 | — | — | EP | claimed |