Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 1.00 |
| ▸ | PPARA | Q07869 | 7/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | HTR2A | P28223 | 2/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.63 |
| ▸ | PPARG | P37231 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ELANE | P08246 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | FABP2 | P12104 | 2/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Beclobrate SCHEMBL49779 | 1.00 | OPRK1 (1.00) | OPRK1PPARACYP1A2CYP3A4ABCB11 | |
| SCHEMBL1935420 | 0.93 | OPRK1 (0.86) | OPRK1PPARACYP1A2CYP3A4ABCB11 | |
| SCHEMBL11071767 | 0.90 | OPRK1 (0.81) | OPRK1PPARACYP1A2CYP3A4ABCB11 | |
| SCHEMBL11063131 | 0.90 | OPRK1 (0.81) | OPRK1PPARACYP1A2CYP3A4ABCB11 | |
| SCHEMBL11070815 | 0.88 | OPRK1 (0.79) | OPRK1PPARACYP1A2CYP3A4ABCB11 | |
| SCHEMBL11470655 | 0.88 | OPRK1 (0.79) | OPRK1PPARACYP1A2CYP3A4ABCB11 | |
| SCHEMBL11068228 | 0.88 | OPRK1 (0.78) | OPRK1PPARACYP1A2CYP3A4ABCB11 | |
| SCHEMBL11072228 | 0.88 | OPRK1 (0.78) | OPRK1PPARACYP1A2CYP3A4ABCB11 | |
| SCHEMBL5997445 | 0.88 | OPRK1 (0.78) | OPRK1PPARACYP1A2CYP3A4ABCB11 | |
| SCHEMBL11074765 | 0.87 | OPRK1 (0.76) | OPRK1PPARACYP1A2CYP3A4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009033078-A2 | COMPOSITIONS AND METHODS FOR CONTROLLING CHOLESTEROL LEVELS | TAWAKOL RAIF (US) | 2009-03-12 | — | — | WO | disclosed |
| EP-1684704-A2 | COMPOSITIONS AND METHODS FOR INCREASING HDL AND HDL-2B LEVELS | Tawakol, Raif M. (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005041878-A2 | COMPOSITIONS AND METHODS FOR INCREASING HDL AND HDL-2B LEVELS | TAWAKOL RAIF M D (US) | 2005-05-12 | — | — | WO | disclosed |
| WO-2000069445-A1 | COMBINATION THERAPY FOR TREATING HYPERCHOLESTEROLEMIA | GELTEX PHARMACEUTICALS, INC. (US) | 2000-11-23 | — | — | WO | disclosed |