Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBK | Q96KB5 | 5/20 | 0.45 |
| ▸ | CPN1 | P15169 | 1/20 | 0.44 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.40 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.40 |
| ▸ | FPR3 | P25089 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13186049 | 1.00 | PBK (0.45) | PBKCPN1CPB2EPHX1ALOX15 | |
| SCHEMBL13212506 | 1.00 | PBK (0.45) | PBKCPN1CPB2EPHX1ALOX15 | |
| SCHEMBL617644 | 0.89 | ALOX15 (0.51) | EPHX1ALOX15SLC6A1SLC6A11TSHR | |
| SCHEMBL9044696 | 0.89 | ALOX15 (0.51) | EPHX1ALOX15SLC6A1SLC6A11TSHR | |
| SCHEMBL617850 | 0.89 | ALOX15 (0.51) | EPHX1ALOX15SLC6A1SLC6A11TSHR | |
| Hydrochloric Acid SCHEMBL715762 | 0.87 | ALOX15 (0.50) | EPHX1ALOX15SLC6A1SLC6A11TSHR | |
| Hydrochloric Acid SCHEMBL715763 | 0.87 | ALOX15 (0.50) | EPHX1ALOX15SLC6A1SLC6A11TSHR | |
| SCHEMBL477374 | 0.84 | CYP2D6 (0.51) | PBKCPN1CPB2EPHX1KMT2A | |
| SCHEMBL5649078 | 0.84 | CYP2D6 (0.51) | PBKCPN1CPB2EPHX1KMT2A | |
| SCHEMBL2768724 | 0.84 | CYP2D6 (0.51) | PBKCPN1CPB2EPHX1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9493444-B2 | Azaheterocyclic compounds | MERCK PATENT GMBH (DE) | 2016-11-15 | — | — | US | disclosed |
| US-9493444-B2 | Azaheterocyclic compounds | MERCK PATENT GMBH (DE) | 2016-11-15 | — | — | US | disclosed |
| EP-2807154-B1 | AZAHETEROCYCLIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-12-23 | — | — | EP | disclosed |
| US-20150005294-A1 | AZAHETEROCYCLIC COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2015-01-01 | — | — | US | disclosed |
| US-20150005294-A1 | AZAHETEROCYCLIC COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2015-01-01 | — | — | US | disclosed |
| WO-2013110433-A1 | AZAHETEROCYCLIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2013-08-01 | — | — | WO | disclosed |
| US-8293729-B2 | Compounds, pharmaceutical composition and methods relating thereto | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-10-23 | — | — | US | disclosed |
| US-20110166116-A1 | NEW COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS RELATING THERETO | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-07-07 | — | — | US | disclosed |
| WO-2010149684-A1 | NEW COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS RELATING THERETO | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-12-29 | — | — | WO | disclosed |
| CN-101460507-A | Thiazolyldihydroindazoles | BOEHRINGER INGELHEIM INT (DE) | 2009-06-17 | — | — | CN | disclosed |
| EP-2018386-A1 | THIAZOLYLDIHYDROINDAZOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-01-28 | — | — | EP | disclosed |
| US-20070259855-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-08 | — | — | US | disclosed |
| WO-2007115930-A1 | THIAZOLYLDIHYDROINDAZOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-18 | — | — | WO | disclosed |
| CN-1665506-A | 2, 5-substituted pyrimidine derivatives as CCR-3 receptor antagonists IX | HOFFMANN LA ROCHE (CH) | 2005-09-07 | — | — | CN | disclosed |
| US-5147882-A | Cardiovascular disorders | KARL THOMAE GMBH (DE) | 1992-09-15 | — | — | US | disclosed |
| EP-0450429-A1 | Cyclophanes, process for their preparation and pharmaceuticals containing them | Dr. Karl Thomae GmbH (DE) | 1991-10-09 | — | — | EP | disclosed |
| US-5051509-A | Antibiotics | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1991-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259855-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | ROR1, RORB, RORA | PBK 2545/4885CPN1 4790/4885CPB2 4432/4885 |
| US-20150005294-A1 | AZAHETEROCYCLIC COMPOUNDS | PCNA, CDKN1A, CCNC | PBK 984/4885CPN1 4692/4885CPB2 4161/4885 |
| US-20110166116-A1 | NEW COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS RELATING THERETO | MC2R, REN, CYP11B2 | PBK 3682/4885CPN1 1793/4885CPB2 1106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.