Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 1/20 | 0.42 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | ADH1B | P00325 | 3/20 | 0.39 |
| ▸ | ADH1C | P00326 | 3/20 | 0.39 |
| ▸ | ADH1A | P07327 | 3/20 | 0.39 |
| ▸ | ADH7 | P40394 | 3/20 | 0.39 |
| ▸ | ADH4 | P08319 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL402125 | 0.89 | SLC6A1 (0.43) | GNAI3GNAO1GNAI1NAMPTADH1B | |
| SCHEMBL4136214 | 0.88 | GNAI3 (0.41) | GNAI3GNAO1GNAI1NAMPTADH1B | |
| SCHEMBL5651899 | 0.86 | — | — | |
| SCHEMBL3024930 | 0.82 | ADH1B (0.54) | ADH1BADH1CADH1AADH7ADH4 | |
| SCHEMBL304406 | 0.80 | ADH1B (0.57) | ADH1BADH1CADH1AADH7ADH4 | |
| SCHEMBL3948570 | 0.78 | ITGB3 (0.39) | GNAI3GNAO1GNAI1NAMPTITGB3 | |
| SCHEMBL22104300 | 0.78 | ADH1B (0.54) | ADH1BADH1CADH1AADH7ADH4 | |
| SCHEMBL303075 | 0.76 | ADH1B (0.57) | ADH1BADH1CADH1AADH7ADH4 | |
| SCHEMBL3030276 | 0.75 | ADH1B (0.61) | GNAI3GNAO1GNAI1ADH1BADH1C | |
| SCHEMBL5963079 | 0.75 | GNAO1 (0.52) | GNAI3GNAO1GNAI1NAMPTITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |