Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL39584 | 0.87 | KDM4E (0.35) | KDM4ELMNAMAPTHPGDHTT | |
| Hydrochloric Acid SCHEMBL38850 | 0.83 | ALDH1A1 (0.37) | KDM4ELMNAMAPTHTT | |
| SCHEMBL4968015 | 0.81 | ALDH1A1 (0.33) | KDM4ELMNAMAPTHPGDHTT | |
| SCHEMBL4970674 | 0.80 | RAPGEF4 (0.34) | KDM4ELMNAMAPTHPGDHTT | |
| Hydrochloric Acid SCHEMBL3671010 | 0.78 | NOS1 (0.33) | — | |
| SCHEMBL16653951 | 0.75 | NOS1 (0.35) | — | |
| SCHEMBL23535362 | 0.74 | NOS1 (0.34) | — | |
| SCHEMBL14830125 | 0.74 | NOS1 (0.34) | — | |
| Hydrochloric Acid SCHEMBL39685 | 0.73 | BACE1 (0.34) | — | |
| Hydrochloric Acid SCHEMBL39915 | 0.73 | LMNA (0.36) | KDM4ELMNAMAPTHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760958-A1 | SYSTEMS, METHODS AND COMPOSITIONS FOR PRODUCTION OF TIE-LAYER ADHESIVES | Equistar Chemicals, LP (US) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013049786-A1 | SYSTEMS, METHODS AND COMPOSITIONS FOR PRODUCTION OF TIE-LAYER ADHESIVES | EQUISTAR CHEMICALS, LP (US) | 2013-04-04 | — | — | WO | disclosed |
| EP-2361281-A1 | IMPACT RESISTANT LLDPE COMPOSITION AND FILMS MADE THEREOF | Basell Polyolefine GmbH (DE) | 2011-08-31 | — | — | EP | disclosed |
| EP-2344551-A1 | IMPACT RESISTANT LLDPE COMPOSITION AND FILMS MADE THEREOF | Basell Polyolefine GmbH (DE) | 2011-07-20 | — | — | EP | disclosed |
| EP-2337811-A1 | IMPACT RESISTANT LLDPE COMPOSITION AND FILMS MADE THEREOF | Basell Polyolefine GmbH (DE) | 2011-06-29 | — | — | EP | disclosed |
| EP-2326678-A1 | IMPACT RESISTANT LLDPE COMPOSITION AND FILMS MADE THEREOF | Basell Polyolefine GmbH (DE) | 2011-06-01 | — | — | EP | disclosed |
| WO-2010034461-A1 | IMPACT RESISTANT LLDPE COMPOSITION AND FILMS MADE THEREOF | BASELL POLYOLEFINE GMBH (DE) | 2010-04-01 | — | — | WO | disclosed |
| WO-2010034520-A1 | IMPACT RESISTANT LLDPE COMPOSITION AND FILMS MADE THEREOF | BASELL POLYOLEFINE GMBH (DE) | 2010-04-01 | — | — | WO | disclosed |
| WO-2010034464-A1 | IMPACT RESISTANT LLDPE COMPOSITION AND FILMS MADE THEREOF | BASELL POLYOLEFINE GMBH (DE) | 2010-04-01 | — | — | WO | disclosed |
| WO-2010034508-A1 | IMPACT RESISTANT LLDPE COMPOSITION AND FILMS MADE THEREOF | BASELL POLYOLEFINE GMBH (DE) | 2010-04-01 | — | — | WO | disclosed |
| WO-2010034463-A1 | IMPACT RESISTANT LLDPE COMPOSITION AND FILMS MADE THEREOF | BASELL POLYOLEFINE GMBH (DE) | 2010-04-01 | — | — | WO | disclosed |