Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | APLNR | P35414 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6390242 | 0.81 | USP2 (0.49) | USP2SMN1; SMN2L3MBTL1POLBMEN1 | |
| SCHEMBL3869275 | 0.79 | APLNR (0.60) | USP2SMN1; SMN2L3MBTL1POLBMEN1 | |
| SCHEMBL145084 | 0.79 | APLNR (0.68) | APLNRALDH1A1TSHRGAAMAPK1 | |
| SCHEMBL5659502 | 0.79 | RAB9A (0.45) | SMN1; SMN2L3MBTL1POLBMEN1KMT2A | |
| SCHEMBL12475472 | 0.78 | USP2 (0.46) | USP2SMN1; SMN2L3MBTL1POLBMEN1 | |
| SCHEMBL28849186 | 0.76 | APLNR (0.47) | USP2APLNRALDH1A1TSHRGAA | |
| SCHEMBL546118 | 0.75 | L3MBTL1 (0.57) | USP2SMN1; SMN2L3MBTL1POLBMEN1 | |
| SCHEMBL25082195 | 0.75 | GPR84 (0.69) | SMN1; SMN2MEN1KMT2ATSHRMAPK1 | |
| SCHEMBL10480569 | 0.74 | MEN1 (0.51) | SMN1; SMN2L3MBTL1MEN1KMT2AHPGD | |
| SCHEMBL14541445 | 0.74 | HTR2A (0.58) | TSHRCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113412267-A | alpha-D-galactoside inhibitors of galectins | 格莱克特生物技术公司 | 2021-09-17 | — | — | CN | disclosed |
| WO-2013041482-A1 | SIDE CHAIN-FUNCTIONALIZED PEG | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V. (DE) | 2013-03-28 | — | — | WO | disclosed |
| US-20090105239-A1 | 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | ASTRAZENECA AB (SE) | 2009-04-23 | — | — | US | disclosed |
| WO-2009037413-A1 | DIMERS OF 5- [ (4-CYANOPHENYL) SULFINYL] -6-METHYL-2-OXO-1- [3- (TRIFLUOROMETHYL)PHENYL] -1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE FOR TREATING RESPIRATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-03-26 | — | — | WO | disclosed |
| EP-1861371-A1 | NOVEL COMPOUNDS II 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE. | AstraZeneca AB (SE) | 2007-12-05 | — | — | EP | disclosed |
| WO-2007107706-A2 | DIMERS OF HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF COPD | ARGENTA DISCOVERY LIMITED (GB) | 2007-09-27 | — | — | WO | disclosed |
| WO-2006098684-A1 | NOVEL COMPOUNDS II 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE. | ASTRAZENECA AB (SE) | 2006-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105239-A1 | 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | SERPINB1, ELANE, MPO | USP2 1178/4885SMN1; SMN2 1429/4885L3MBTL1 3575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.