Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.32 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GALR3 | O60755 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3878819 | 0.98 | TSHR (0.42) | ALDH1A1LMNAAPEX1TSHRCHRM5 | |
| Iodide SCHEMBL10588908 | 0.95 | TSHR (0.40) | ALDH1A1LMNAAPEX1TSHRTDP1 | |
| Hydrochloric Acid SCHEMBL10871497 | 0.85 | ALDH1A1 (0.48) | ALDH1A1LMNAAPEX1TSHRBLM | |
| SCHEMBL10481784 | 0.77 | BBOX1 (0.36) | — | |
| Hydrochloric Acid SCHEMBL8166002 | 0.77 | ACHE (0.41) | ALDH1A1LMNAAPEX1TSHRBLM | |
| Glycinebetaine SCHEMBL7771573 | 0.70 | TSHR (0.44) | ALDH1A1LMNAAPEX1TSHRTDP1 | |
| Betaine SCHEMBL5965072 | 0.70 | TSHR (0.64) | ALDH1A1LMNAAPEX1TSHRTDP1 | |
| SCHEMBL5137154 | 0.69 | — | — | |
| SCHEMBL10435380 | 0.69 | — | — | |
| Methacrylic Acid SCHEMBL873040 | 0.68 | POLB (0.38) | ALDH1A1LMNAAPEX1TSHRBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1302514-B1 | Active energy ray-curable antistatic coating composition | MITSUBISHI CHEM CORP (JP) | 2009-07-15 | — | — | EP | disclosed |
| US-20090056896-A1 | AQUEOUS DISPERSION OF PRECIPITATED CALCIUM CARBONATE STARTING FROM AT LEAST ONE DISPERSING AGENT COMPRISING A COMPOUND CARRYING FLUORIDE IONS | COATEX S.A.S. (FR) | 2009-03-05 | — | — | US | disclosed |
| US-20080233281-A1 | PROCESS FOR PRODUCING AN OPTICAL ELEMENT | DAI NIPPON PRINTING CO., LTD. (JP) | 2008-09-25 | — | — | US | disclosed |
| US-20060035033-A1 | Spray coating method, spray coating device and inkjet recording sheet | KONICA MINOLTA PHOTO IMAGING, INC. | 2006-02-16 | — | — | US | disclosed |
| US-6921576-B2 | Active energy ray-curable antistatic coating composition | MITSUBISHI CHEMICAL CORPORATION (JP) | 2005-07-26 | — | — | US | disclosed |
| EP-1552951-A2 | Porous type inkjet recording sheet and method of forming the same | KONICA MINOLTA HOLDINGS, INC. (JP) | 2005-07-13 | — | — | EP | disclosed |
| US-20050147769-A1 | Porous type inkjet recording sheet and forming method of the same | KONICA MINOLTA HOLDINGS, INC. | 2005-07-07 | — | — | US | disclosed |
| US-20050129876-A1 | Composition for orientation film formation | DAI NIPPON PRINTING CO., LTD. (JP) | 2005-06-16 | — | — | US | disclosed |
| EP-1302514-A2 | Active energy ray-curable antistatic coating composition | MITSUBISHI CHEMICAL CORPORATION (JP) | 2003-04-16 | — | — | EP | disclosed |
| US-4678581-A | Polymethyl methacrylate hollow fiber type ultrafiltration membrane and process for preparation of the same | TORAY INDUSTRIES, INC. (JP) | 1987-07-07 | — | — | US | disclosed |
| EP-0210073-A2 | Aqueous deodorants and deodorizing methods | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1987-01-28 | — | — | EP | disclosed |
| EP-0092587-B1 | POLYMETHYL METHACRYLATE HOLLOW YARN ULTRA-FILTRATION MEMBRANE AND PROCESS FOR ITS PRODUCTION | TORAY INDUSTRIES, INC. (JP) | 1986-09-03 | — | — | EP | disclosed |
| EP-0092587-A1 | POLYMETHYL METHACRYLATE HOLLOW YARN ULTRA-FILTRATION MEMBRANE AND PROCESS FOR ITS PRODUCTION | TORAY INDUSTRIES, INC. (JP) | 1983-11-02 | — | — | EP | disclosed |