Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 5/20 | 0.46 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.42 |
| ▸ | MMP7 | P09237 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4304990 | 0.79 | GPR88 (0.44) | GPR88MMP1MMP2MMP3MMP9 | |
| SCHEMBL2163024 | 0.78 | GPR88 (0.56) | GPR88ALDH1A1GLATSHR | |
| SCHEMBL173483 | 0.76 | ALDH1A1 (0.49) | MMP1MMP2MMP3MMP9MMP13 | |
| Naphthalene SCHEMBL6841195 | 0.72 | ALDH1A1 (0.53) | MMP1MMP2MMP3MMP9MMP13 | |
| SCHEMBL4957420 | 0.71 | ALDH1A1 (0.47) | GPR88ALDH1A1GLATSHR | |
| SCHEMBL6252531 | 0.71 | ALDH1A1 (0.49) | GPR88MMP2MMP9MMP13ALDH1A1 | |
| SCHEMBL27654625 | 0.70 | ALDH1A1 (0.60) | GPR88ALDH1A1GLATSHR | |
| SCHEMBL2170762 | 0.70 | MEN1 (0.43) | GPR88CTSBALDH1A1GLATSHR | |
| SCHEMBL11262493 | 0.69 | ALDH1A1 (0.58) | ALDH1A1GLATSHR | |
| SCHEMBL4867352 | 0.69 | CTSS (0.42) | CTSBALDH1A1GLATSHRCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706402-A4 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2009-03-18 | — | — | EP | claimed |
| EP-1706402-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2006-10-04 | — | — | EP | claimed |
| WO-2005066159-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2005-07-21 | — | — | WO | claimed |
| US-20090176859-A1 | Cathepsin cysteine protease inhibitors | MERCK FROSST CANADA, LTD. (CA) | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176859-A1 | Cathepsin cysteine protease inhibitors | CTSE, CTSB, CTSS | GPR88 945/4885MMP1 426/4885MMP2 577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.