SCHEMBL396609

SCHEMBL396609

CC(C)S(=O)(=O)c1ccc(N)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.54
LMNA P02545 2/20 0.54
HTR6 P50406 2/20 0.54
MPO P05164 1/20 0.54
CYP3A4 P08684 1/20 0.54
CYP2C9 P11712 1/20 0.54
CA2 P00918 5/20 0.52
CA1 P00915 4/20 0.52
CA12 O43570 4/20 0.52
CA9 Q16790 4/20 0.52
CA14 Q9ULX7 2/20 0.52
TDP1 Q9NUW8 2/20 0.52
AGO2 Q9UKV8 2/20 0.52
USP2 O75604 1/20 0.52
CA4 P22748 1/20 0.52
CA6 P23280 1/20 0.52
CA5A P35218 1/20 0.52
CA7 P43166 1/20 0.52
CA13 Q8N1Q1 1/20 0.52
CA5B Q9Y2D0 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10060475 0.87 ALDH1A1 (0.40) CA2CA1CA12CA9CA14
SCHEMBL8951866 0.82 TSHR (0.50) TSHRLMNAHTR6MPOCYP3A4
SCHEMBL7758469 0.82 TSHR (0.52) TSHRLMNAHTR6MPOCYP3A4
SCHEMBL105259 0.81 ALDH1A1 (0.50) LMNACA2CA1CA12CA9
SCHEMBL10060466 0.80 CA12 (0.46) LMNACA2CA1CA12CA9
SCHEMBL2657775 0.78 ALDH1A1 (0.36) CA2CA1CA12CA9CA14
SCHEMBL178444 0.78 GAA (0.56) TSHRLMNACYP3A4CYP2C9CA2
SCHEMBL14520771 0.78 ENPP2 (0.52)
SCHEMBL17315251 0.77 CA2 (0.60) TSHRHTR6CA2CA1CA12
SCHEMBL17373703 0.77 TSHR (0.45) TSHRLMNAHTR6MPOCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 468 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7468231-B2 Imaging members XEROX CORPORATION (US) 2008-12-23 US claimed
EP-1773768-A4 PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS EXELIXIS INC (US) 2008-08-06 EP claimed
EP-1773768-A2 PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS Exelixis, Inc. (US) 2007-04-18 EP claimed
US-20060177751-A1 Imaging members XEROX CORPORATION 2006-08-10 US claimed
WO-2006012642-A2 PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS EXELIXIS, INC. (US) 2006-02-02 WO claimed
US-20240270699-A1 COMPOUNDS HAVING N-ARYLPYRIMIDIN-2-AMINE DERIVATIVES AS THERAPEUTIC AGENTS LOMOND THERAPEUTICS, INC. 2024-08-15 US disclosed
US-11760775-B2 Steroids and protein-conjugates thereof REGENERON PHARMACEUTICALS, INC. 2023-09-19 US disclosed
US-11760775-B2 Steroids and protein-conjugates thereof REGENERON PHARMACEUTICALS, INC. 2023-09-19 US disclosed
US-11673870-B2 Pharmaceutical compounds SAREUM LIMITED (GB) 2023-06-13 US disclosed
US-11673870-B2 Pharmaceutical compounds SAREUM LIMITED (GB) 2023-06-13 US disclosed
WO-2023043630-A1 COMPOUNDS HAVING N-ARYLPYRIMIDIN-2-AMINE DERIVATIVES AS THERAPEUTIC AGENTS LOMOND THERAPEUTICS, INC. (US) 2023-03-23 WO disclosed
US-20210087154-A1 PHARMACEUTICAL COMPOUNDS SAREUM LIMITED (GB) 2021-03-25 US disclosed
EP-0289216-A2 Electrophotographic imaging member XEROX CORPORATION (US) 1988-11-02 EP disclosed
US-4780385-A GREATER RESISTANCE TO FORMATION OF CHARGE DEFICIENT SPOTS XEROX CORPORATION (US) 1988-10-25 US disclosed
EP-0149914-B1 OVERCOATED ELECTROPHOTOGRAPHIC IMAGING MEMBER XEROX CORPORATION (US) 1988-08-10 EP disclosed
US-4588667-A Electrophotographic imaging member and process comprising sputtering titanium on substrate XEROX CORPORATION (US) 1986-05-13 US disclosed
EP-0161933-A2 Electrophotographic imaging XEROX CORPORATION (US) 1985-11-21 EP disclosed
EP-0149914-A1 Overcoated electrophotographic imaging member XEROX CORPORATION (US) 1985-07-31 EP disclosed
US-4515882-A CHARGE TRANSFER COMPOUNDS AND CHARGE INJECTION ENABLING PARTICLES XEROX CORPORATION (US) 1985-05-07 US disclosed
US-4303673-A N-Propionylsarcosineanilides, process for their preparation, and pharmaceutical compositions containing them A. NATTERMANN & CIE. GMBH (DE) 1981-12-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240270699-A1 COMPOUNDS HAVING N-ARYLPYRIMIDIN-2-AMINE DERIVATIVES AS THERAPEUTIC AGENTS IRAK3, IRAK1, IRAK2 TSHR 2092/4885LMNA 3635/4885HTR6 1141/4885
US-11673870-B2 Pharmaceutical compounds TYK2, JAK2, SGK2 TSHR 1644/4885LMNA 3390/4885HTR6 1642/4885
US-20210087154-A1 PHARMACEUTICAL COMPOUNDS TYK2, JAK2, SGK2 TSHR 1644/4885LMNA 3390/4885HTR6 1642/4885
US-11760775-B2 Steroids and protein-conjugates thereof SERPINA6, NR3C1, NR3C2 TSHR 809/4885LMNA 3616/4885HTR6 4196/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.