SCHEMBL3968908

SCHEMBL3968908

CC1=CC(=O)CN(c2ccc(C)cc2)C1

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
F2 P00734 1/20 0.42
ELANE P08246 1/20 0.42
CTSG P08311 1/20 0.42
CMA1 P23946 1/20 0.42
CTRC Q99895 1/20 0.42
ADRB1 P08588 1/20 0.41
MAPT P10636 2/20 0.40
MGLL Q99685 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
LMNA P02545 1/20 0.38
RAB9A P51151 2/20 0.38
NPC1 O15118 1/20 0.38
PKM P14618 1/20 0.38
ALOX5 P09917 1/20 0.37
AKR1C3 P42330 1/20 0.37
GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3967446 0.85 MAPT (0.48) ADRB1MAPTMEN1KMT2ARAB9A
SCHEMBL4283993 0.82 POLB (0.46) ADRB1MAPTMGLLMEN1KMT2A
SCHEMBL3970586 0.69 ADRA1A (0.35) MAPTMEN1KMT2ALMNARAB9A
SCHEMBL21262494 0.68 ADRB1 (0.44) F2ELANECTSGCMA1CTRC
SCHEMBL31432954 0.67 MAPT (0.67) ADRB1MAPTMEN1KMT2ARAB9A
SCHEMBL13232537 0.67 MAPT (0.67) ADRB1MAPTMEN1KMT2ARAB9A
SCHEMBL9832282 0.67 ADRB1 (0.47) F2ELANECTSGCMA1CTRC
SCHEMBL10063748 0.67 ADRB1 (0.70) ADRB1MAPTMEN1KMT2ALMNA
SCHEMBL9678667 0.67 ADRB1 (0.56) F2ELANECTSGCMA1CTRC
SCHEMBL7105773 0.67 ADRB1 (0.70) ADRB1MAPTMEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0866656-B1 USE OF N-SUBSTITUTED PYRIDONES AS TUMOR NECROSIS FACTOR ALPHA INHIBITORS MARGOLIN SOLOMON B (US) 2007-04-25 EP claimed
EP-0813409-B1 TREATMENT OF CYTOKINE GROWTH FACTOR CAUSED DISORDERS MARGOLIN SOLOMON B (US) 2004-05-06 EP claimed
US-5962478-A ADMINISTERING A N-SUBSTITUTED 2(1H)PYRIDONE INTERMUNE, INC. 1999-10-05 US claimed
US-20250268821-A1 NINTEDANIB AND NINTEDANIB COMBINATION DRY POWDER COMPOSITIONS AND USES AVALYN PHARMA INC. 2025-08-28 US disclosed
US-20250177294-A1 NINTEDANIB AND NINTEDANIB COMBINATION DRY POWDER COMPOSITIONS AND USES AVALYN PHARMA INC. 2025-06-05 US disclosed
US-20250114376-A1 AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF AVALYN PHARMA INC. 2025-04-10 US disclosed
US-12226407-B2 Aerosol pirfenidone and pyridone analog compounds and uses thereof AVALYN PHARMA INC. (US) 2025-02-18 US disclosed
EP-4491180-A1 AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF Avalyn Pharma Inc. (US) 2025-01-15 EP disclosed
EP-3091976-B1 AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF AVALYN PHARMA INC (US) 2024-07-24 EP disclosed
US-12023342-B2 Aerosol pirfenidone and pyridone analog compounds and uses thereof AVALYN PHARMA INC. (US) 2024-07-02 US disclosed
US-20230330357-A1 NEBULIZER DEVICE OPTIMIZATION FOR IMPROVED AEROSOL PARAMETERS AND USES THEREOF AVALYN PHARMA INC. 2023-10-19 US disclosed
WO-2012106382-A1 AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF GENOA PHARMACEUTICALS, INC. (US) 2012-08-09 WO disclosed
US-20120192861-A1 AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF GENOA PHARMACEUTICALS, INC. (US) 2012-08-02 US disclosed
US-20090286843-A1 MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION HOFFMANN-LA ROCHE INC. 2009-11-19 US disclosed
US-20090111982-A1 MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION HOFFMANN-LA ROCHE INC. 2009-04-30 US disclosed
US-20090105471-A1 MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION HOFFMANN-LA ROCHE INC. 2009-04-23 US disclosed
US-7491794-B2 Macrocyclic compounds as inhibitors of viral replication INTERMUNE, INC. (US) 2009-02-17 US disclosed
US-20060198823-A1 Compositions and methods for treating viral infections INTERMUNE, INC. 2006-09-07 US disclosed
US-20050267018-A1 Macrocyclic compounds as inhibitors of viral replication HOFFMANN-LA ROCHE INC. 2005-12-01 US disclosed
US-5962478-A ADMINISTERING A N-SUBSTITUTED 2(1H)PYRIDONE INTERMUNE, INC. 1999-10-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090111982-A1 MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION EIF2AK2, HAVCR2, ZC3HAV1 F2 117/4885ELANE 649/4885CTSG 1716/4885
US-20250268821-A1 NINTEDANIB AND NINTEDANIB COMBINATION DRY POWDER COMPOSITIONS AND USES INF2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, IPO5 F2 926/4885ELANE 283/4885CTSG 4087/4885
US-20090286843-A1 MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION EIF2AK2, HAVCR2, ZC3HAV1 F2 117/4885ELANE 649/4885CTSG 1716/4885
US-20060198823-A1 Compositions and methods for treating viral infections IFNAR1, IFNG, TLR3 F2 594/4885ELANE 1863/4885CTSG 621/4885
US-20250114376-A1 AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF PLPBP, PIR, PDXK F2 166/4885ELANE 1574/4885CTSG 4667/4885
US-20120192861-A1 AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF PLPBP, PIR, PDXK F2 166/4885ELANE 1574/4885CTSG 4667/4885
US-20050267018-A1 Macrocyclic compounds as inhibitors of viral replication EIF2AK2, HAVCR2, ZC3HAV1 F2 117/4885ELANE 649/4885CTSG 1716/4885
US-12023342-B2 Aerosol pirfenidone and pyridone analog compounds and uses thereof PLPBP, PIR, PDXK F2 166/4885ELANE 1574/4885CTSG 4667/4885
US-20250177294-A1 NINTEDANIB AND NINTEDANIB COMBINATION DRY POWDER COMPOSITIONS AND USES INF2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, IPO5 F2 926/4885ELANE 283/4885CTSG 4087/4885
US-20090105471-A1 MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION EIF2AK2, HAVCR2, ZC3HAV1 F2 117/4885ELANE 649/4885CTSG 1716/4885
US-12226407-B2 Aerosol pirfenidone and pyridone analog compounds and uses thereof PLPBP, PIR, PDXK F2 166/4885ELANE 1574/4885CTSG 4667/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.