Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SCN2B | O60939 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.41 |
| ▸ | METTL14 | Q9HCE5 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3976494 | 0.92 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2HDAC1HDAC2 | |
| SCHEMBL13883750 | 0.91 | ABCB1 (0.42) | NPC1RAB9ASMN1; SMN2KCNH2HDAC1 | |
| SCHEMBL3971172 | 0.82 | PTAFR (0.48) | NPC1RAB9ASMN1; SMN2LMNAHPGD | |
| SCHEMBL13883740 | 0.81 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2HDAC1HDAC2 | |
| SCHEMBL3972294 | 0.81 | NAMPT (0.48) | HDAC1HDAC2PLA2G4A | |
| SCHEMBL3971256 | 0.80 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2HDAC1HDAC2 | |
| SCHEMBL13883686 | 0.79 | RORC (0.45) | NPC1RAB9ASMN1; SMN2LMNASCN2B | |
| SCHEMBL3967303 | 0.77 | PKM (0.48) | NPC1 | |
| SCHEMBL13883906 | 0.77 | TMEM97 (0.45) | NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL3975570 | 0.76 | RAB9A (0.47) | RAB9AHDAC1HDAC2PLA2G4ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | claimed |
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |