Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | APEX1 | P27695 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1598651 | 0.78 | ALDH1A1 (0.46) | MAPTHSD17B10ALDH1A1KDM4EPOLB | |
| SCHEMBL546834 | 0.77 | MAPT (0.59) | TTRMAPTAPEX1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL3043164 | 0.76 | MAPT (0.57) | TTRMAPTAPEX1NPC1RAB9A | |
| SCHEMBL8978501 | 0.76 | GPR35 (0.44) | GLAGPR35HSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL8630653 | 0.74 | TTR (0.57) | TTRMAPTAPEX1NPC1RAB9A | |
| SCHEMBL31619086 | 0.74 | TTR (0.66) | TTRMAPTAPEX1NPC1RAB9A | |
| SCHEMBL11718003 | 0.72 | MAPT (0.50) | TTRMAPTAPEX1NPC1RAB9A | |
| SCHEMBL11722067 | 0.71 | TTR (0.68) | TTRMAPTAPEX1NPC1RAB9A | |
| SCHEMBL3907975 | 0.71 | TTR (0.58) | TTRMAPTAPEX1NPC1RAB9A | |
| SCHEMBL10715763 | 0.71 | PIM1 (0.36) | MAPTAPEX1NPC1RAB9AGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240317708-A1 | INHIBITORS OF TRANSGLUTAMINASES | ZEDIRA GMBH (DE) | 2024-09-26 | — | — | US | disclosed |
| EP-4192812-B1 | INHIBITORS OF TRANSGLUTAMINASES | ZEDIRA GMBH (DE) | 2024-09-04 | — | — | EP | disclosed |
| CN-117561240-A | Inhibitors of transglutaminase | 策迪拉有限公司 | 2024-02-13 | — | — | CN | disclosed |
| EP-4192812-A1 | INHIBITORS OF TRANSGLUTAMINASES | Zedira GmbH (DE) | 2023-06-14 | — | — | EP | disclosed |
| US-20230124700-A1 | OXAZOLE AND THIOAZOLE-TYPE CULLIN RING UBIQUITIN LIGASE COMPOUNDS AND USES THEREOF | CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH (AT) | 2023-04-20 | — | — | US | disclosed |
| WO-2023275333-A1 | INHIBITORS OF TRANSGLUTAMINASES | ZEDIRA GMBH (DE) | 2023-01-05 | — | — | WO | disclosed |
| EP-4045142-A1 | OXAZOLE AND THIOAZOLE-TYPE CULLIN RING UBIQUITIN LIGASE COMPOUNDS AND USES THEREOF | CeMM - Forschungszentrum für Molekulare Medizin GmbH (AT) | 2022-08-24 | — | — | EP | disclosed |
| WO-2021074414-A1 | OXAZOLE AND THIOAZOLE-TYPE CULLIN RING UBIQUITIN LIGASE COMPOUNDS AND USES THEREOF | CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH (AT) | 2021-04-22 | — | — | WO | disclosed |
| WO-2021074414-A1 | OXAZOLE AND THIOAZOLE-TYPE CULLIN RING UBIQUITIN LIGASE COMPOUNDS AND USES THEREOF | CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH (AT) | 2021-04-22 | — | — | WO | disclosed |
| EP-1732882-B1 | NON-GLYCOSYLATED/NON-GLYCOSIDIC/NON-PEPTIDIC SMALL MOLECULE PSGL-1 MIMETICS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | REVOTAR BIOPHARMACEUTICALS AG (DE) | 2012-07-04 | — | — | EP | disclosed |
| WO-2005037812-A1 | FURAN DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | ASTERAND UK LIMITED (GB) | 2005-04-28 | — | — | WO | disclosed |
| US-4945177-A | Antimicrobially active nitriles and the production thereof | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1990-07-31 | — | — | US | disclosed |
| US-4728743-A | Process for the production of 3-oxonitriles | DEGUSSA AKTIENGESELLSCHAFT (DE) | 1988-03-01 | — | — | US | disclosed |
| US-4716237-A | Process for the production of 3-oxonitriles | DEGUSSA AKTIENGESELLSCHAFT (DE) | 1987-12-29 | — | — | US | disclosed |
| EP-0220250-A1 | UTILIZATION OF NITRILES AS ANTIMICROBIAL AGENTS | Henkel Kommanditgesellschaft auf Aktien (DE) | 1987-05-06 | — | — | EP | disclosed |
| EP-0220220-A1 | Process of preparing 2,2-dibromo-3-oxonitriles. | HENKEL KGAA (DE) | 1987-05-06 | — | — | EP | disclosed |
| WO-1986006254-A1 | UTILIZATION OF NITRILES AS ANTIMICROBIAL AGENTS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1986-11-06 | — | — | WO | disclosed |
| WO-1986006369-A1 | ANTI-MICROBIAL NITRILE AND ITS PRODUCTION | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1986-11-06 | — | — | WO | disclosed |
| EP-0089011-B1 | PROCESS FOR THE PREPARATION OF 5-OXONITRILES | Degussa Aktiengesellschaft (DE) | 1985-07-10 | — | — | EP | disclosed |
| EP-0089011-A1 | Process for the preparation of 5-oxonitriles | Degussa Aktiengesellschaft (DE) | 1983-09-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230124700-A1 | OXAZOLE AND THIOAZOLE-TYPE CULLIN RING UBIQUITIN LIGASE COMPOUNDS AND USES THEREOF | CUL1, CUL5, CUL3 | TTR 2116/4885MAPT 560/4885APEX1 1820/4885 |
| US-20240317708-A1 | INHIBITORS OF TRANSGLUTAMINASES | TGM2, TGM3, TGM1 | TTR 682/4885MAPT 989/4885APEX1 3071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.