SCHEMBL397275

SCHEMBL397275

Nc1ccccc1-c1ccc(F)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.65
HSD17B10 Q99714 1/20 0.65
L3MBTL1 Q9Y468 1/20 0.55
PTGS2 P35354 2/20 0.52
PTGS1 P23219 1/20 0.52
ADORA1 P30542 2/20 0.44
DAPK3 O43293 1/20 0.44
PRKD3 O94806 1/20 0.44
MAP4K4 O95819 1/20 0.44
PAK4 O96013 1/20 0.44
ABL1 P00519 1/20 0.44
NTRK1 P04629 1/20 0.44
LCK P06239 1/20 0.44
CSF1R P07333 1/20 0.44
RET P07949 1/20 0.44
IGF1R P08069 1/20 0.44
MET P08581 1/20 0.44
PDGFRB P09619 1/20 0.44
FGFR1 P11362 1/20 0.44
PRKACA P17612 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL28010893 0.98 ALDH1A1 (0.62) ALDH1A1HSD17B10L3MBTL1PTGS2PTGS1
SCHEMBL6480845 0.87 ALDH1A1 (0.83) ALDH1A1HSD17B10L3MBTL1ALOX5APFEN1
SCHEMBL31264295 0.85 ALDH1A1 (0.79) ALDH1A1HSD17B10L3MBTL1ALOX5APFEN1
SCHEMBL21020927 0.82 DAPK3 (0.46) ALDH1A1HSD17B10L3MBTL1PTGS2PTGS1
SCHEMBL15365208 0.82 KDR (0.46) ALDH1A1HSD17B10L3MBTL1PTGS2PTGS1
SCHEMBL29315494 0.81 ALDH1A1 (0.47) ALDH1A1HSD17B10L3MBTL1PTGS2PTGS1
SCHEMBL712916 0.80 ALDH1A1 (0.90) ALDH1A1HSD17B10L3MBTL1SMN1; SMN2CYP3A4
SCHEMBL29510158 0.80 ALDH1A1 (0.71) ALDH1A1HSD17B10L3MBTL1KDRSMN1; SMN2
SCHEMBL599657 0.80 ALDH1A1 (0.71) ALDH1A1HSD17B10L3MBTL1KDRSMN1; SMN2
SCHEMBL25981 0.79 ALDH1A1 (1.00) ALDH1A1HSD17B10L3MBTL1MAP4K4CSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 157 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1252140-B1 PYRROLECARBOXAMIDES AND PYRROLETHIOAMIDES AS FUNGICIDES SYNGENTA PARTICIPATIONS AG (CH) 2009-05-13 EP claimed
US-6355616-B1 FUNGICIDE OLIGOPEOTIDES XOMA (US) TECHNOLOGY LTD. 2002-03-12 US claimed
WO-2026086794-A1 ANTIMICROBIAL COMPOUNDS AND METHODS OF USE THEREOF THE CHINESE UNIVERSITY OF HONG KONG (CN) 2026-04-30 WO disclosed
US-20260001873-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2026-01-01 US disclosed
US-12384772-B2 Inhibitors VIVORYON THERAPEUTICS N.V. (DE) 2025-08-12 US disclosed
US-20220274977-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2022-09-01 US disclosed
CN-114530213-A 2D molecular descriptor-based PAHs carcinogenicity prediction method and prediction model 北京工业大学 2022-05-24 CN disclosed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US disclosed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US disclosed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US disclosed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US disclosed
WO-2001053259-A1 PYRROLECARBOXAMIDES AND PYRROLETHIOAMIDES AS FUNGICIDES SYNGENTA PARTICIPATIONS AG (CH) 2001-07-26 WO disclosed
US-5514773-A PARASITICIDES, ANTHELMINTICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-05-07 US disclosed
EP-0536151-B1 ORTHOSUBSTITUTED BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM BOOTS CO PLC (GB) 1994-09-14 EP disclosed
US-5302720-A Biphenyl-substituted guanidine derivatives useful as hypoglycaemic agents THE BOOTS COMPANY (GB) 1994-04-12 US disclosed
WO-1992000273-A1 ORTHOSUBSTITUTED BIPHENYL AMIDINE AND BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM THE BOOTS COMPANY PLC (GB) 1992-01-09 WO disclosed
EP-0241559-B1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-10-30 EP disclosed
US-4983751-A Chemical intermediates SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-01-08 US disclosed
US-4818272-A NONPHYTOTOXICITY FOR CROPS HELICAL STREAMS SAGAMI CHEMICAL RESEARCH CENTER (JP) 1989-04-04 US disclosed
EP-0241559-A1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1987-10-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260001873-A1 NOVEL INHIBITORS GLS, GLS2, SULT1E1 ALDH1A1 1183/4885HSD17B10 786/4885L3MBTL1 2577/4885
US-20200377493-A1 NOVEL INHIBITORS GLUL, GLS, QPCT ALDH1A1 1681/4885HSD17B10 1015/4885L3MBTL1 3843/4885
US-11339152-B2 Inhibitors GLUL, QPCT, GLS ALDH1A1 1490/4885HSD17B10 963/4885L3MBTL1 3874/4885
US-12384772-B2 Inhibitors GLS, QPCT, GLS2 ALDH1A1 1415/4885HSD17B10 1103/4885L3MBTL1 3883/4885
US-20220274977-A1 NOVEL INHIBITORS GLUL, GLS, QPCT ALDH1A1 1184/4885HSD17B10 935/4885L3MBTL1 3331/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.