Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.54 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | SCN2B | O60939 | 1/20 | 0.47 |
| ▸ | SCN1A | P35498 | 1/20 | 0.47 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972960 | 0.88 | ALDH1A1 (0.59) | FGFR1ALDH1A1KDM4ESCN2BSCN1A | |
| SCHEMBL13883667 | 0.87 | ALDH1A1 (0.51) | ALDH1A1KDM4ESCN2BSCN1ASCN1B | |
| SCHEMBL3973576 | 0.84 | MAPT (0.50) | FGFR1NR4A2ALDH1A1KDM4ESCN2B | |
| SCHEMBL13883742 | 0.84 | MAPT (0.50) | FGFR1NR4A2ALDH1A1KDM4ESCN2B | |
| SCHEMBL3976736 | 0.83 | NR4A2 (0.54) | FGFR1NR4A2ALDH1A1KDM4ESCN2B | |
| SCHEMBL3968490 | 0.82 | POLB (0.53) | FGFR1ALDH1A1KDM4EGLAHPGD | |
| SCHEMBL3974115 | 0.82 | NR4A2 (0.63) | FGFR1NR4A2ALDH1A1KDM4ESCN2B | |
| SCHEMBL13883737 | 0.80 | FGFR1 (0.44) | FGFR1NR4A2ALDH1A1KDM4ESCN2B | |
| SCHEMBL2161419 | 0.80 | CNR2 (0.56) | ALDH1A1TDP1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL28027053 | 0.79 | HTR6 (0.55) | FGFR1ALDH1A1KDM4EHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |