Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HNF4A | P41235 | 1/20 | 0.42 |
| ▸ | KDM6B | O15054 | 5/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.41 |
| ▸ | BRS3 | P32247 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 2/20 | 0.41 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3547750 | 0.86 | HNF4A (0.49) | HNF4AKDM6BKDM4CTDO2KDM4D | |
| SCHEMBL316483 | 0.77 | MCL1 (0.38) | KDM6BKDM4CTDO2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL10739147 | 0.76 | MCL1 (0.37) | KDM6BKDM4CTDO2NPC1RAB9A | |
| SCHEMBL3547880 | 0.75 | GABRP (0.45) | KDM6BKDM4CBRS3KDM4DKDM5B | |
| SCHEMBL15013626 | 0.74 | L3MBTL1 (0.47) | FFAR1NPC1RAB9ASMN1; SMN2DAO | |
| Phthalic Acid SCHEMBL4430760 | 0.73 | ALDH1A1 (0.70) | FFAR1NPC1RAB9ASMN1; SMN2DAO | |
| SCHEMBL9392601 | 0.73 | KDM4E (0.31) | TDO2SMN1; SMN2KDM4E | |
| SCHEMBL11413821 | 0.73 | KAT8 (0.45) | KDM6BNPC1RAB9ASMN1; SMN2KDM4D | |
| SCHEMBL3988801 | 0.73 | TDO2 (0.35) | HNF4AKDM4CTDO2SMN1; SMN2 | |
| SCHEMBL4145759 | 0.73 | DHODH (0.43) | KDM6BKDM4CTDO2RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051977-A2 | SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLbeta-HSD-1 | Amgen Inc. (US) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008011453-A2 | SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLβ-HSD-1 | AMGEN INC. (US) | 2008-01-24 | — | — | WO | disclosed |