Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5107072 | 0.80 | SLC6A4 (0.44) | SLC6A4 | |
| SCHEMBL5097700 | 0.79 | PTGDR2 (0.46) | PKMMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2949180 | 0.73 | PKM (0.70) | PKMSMN1; SMN2 | |
| SCHEMBL2945856 | 0.72 | ALDH1A1 (0.58) | PKMMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9369460 | 0.71 | LMNA (0.58) | PKMMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11771510 | 0.71 | PKM (0.58) | PKMMAPTMEN1KMT2ARECQL | |
| SCHEMBL3949993 | 0.71 | PKM (0.50) | PKMMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL10746832 | 0.71 | HAO1 (0.51) | MAPTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL7814039 | 0.71 | CES2 (0.50) | KMT2AHPGDALOX15HTTNPSR1 | |
| SCHEMBL7878279 | 0.71 | MAPT (0.59) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582676-B2 | 2-phenylpyran-4-one derivatives as selective COX-2 inhibitors | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-09-01 | — | — | US | disclosed |
| EP-1592680-B9 | 2-PHENYLPYRAN-4-ONE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | ALMIRALL LAB (ES) | 2009-03-25 | — | — | EP | disclosed |
| EP-1592680-B1 | 2-PHENYLPYRAN-4-ONE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | ALMIRALL LAB (ES) | 2008-05-07 | — | — | EP | disclosed |
| US-7354936-B2 | 2-phenylpyran-4-one derivatives | ALMIRALL AG (CH) | 2008-04-08 | — | — | US | disclosed |
| US-20060142380-A1 | 2-Phenylpyran-4-one derivatives as selective cox-2 inhibitors | LABORATORIOS ALMIRALL, S.A. (ES) | 2006-06-29 | — | — | US | disclosed |
| EP-1592680-A1 | 2-PHENYLPYRAN-4-ONE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2005-11-09 | — | — | EP | disclosed |
| WO-2004072058-A1 | 2-PHENYLPYRAN-4-ONE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | ALMIRALL PRODESFARMA S.A. (ES) | 2004-08-26 | — | — | WO | disclosed |
| EP-1263751-B1 | 2-PHENYLPYRAN-4-ONE DERIVATIVES | ALMIRALL PRODESFARMA AG (CH) | 2004-06-16 | — | — | EP | disclosed |
| US-20030232880-A1 | 2-Phenylpyran-4-one derivatives | LABORATORIOS ALMIRALL, S.A. (ES) | 2003-12-18 | — | — | US | disclosed |
| US-6518303-B2 | Selectively inhibit COX-2 in preference to COX-1 and are useful in the treatment of COX-2 mediated diseases, such as inflammation, pain, fever and asthma with fewer side effects | ALMIRALL PRODESFARMA S.A. (ES) | 2003-02-11 | — | — | US | disclosed |
| EP-1115716-B1 | 2-PHENYLPYRAN-4-ONE DERIVATIVES | ALMIRALL PRODESFARMA AG (CH) | 2003-01-02 | — | — | EP | disclosed |
| US-20020045644-A1 | 2-phenylpyran-4-one derivatives | LABORATORIES ALMIRALL, S.A. (ES) | 2002-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142380-A1 | 2-Phenylpyran-4-one derivatives as selective cox-2 inhibitors | PTGS2, PTGES2, PTGS1 | PKM 404/4885MAPT 3547/4885MEN1 4765/4885 |
| US-20030232880-A1 | 2-Phenylpyran-4-one derivatives | CYP3A4, UGT1A4, CYP4B1 | PKM 214/4885MAPT 3070/4885MEN1 2375/4885 |
| US-20020045644-A1 | 2-phenylpyran-4-one derivatives | NR4A1, CYP3A4, HTR4 | PKM 352/4885MAPT 3658/4885MEN1 4103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.