Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 6/20 | 0.33 |
| ▸ | CASP7 | P55210 | 6/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972580 | 0.84 | DHODH (0.33) | KDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL3990181 | 0.75 | RORC (0.39) | L3MBTL1MCL1MEN1KMT2A | |
| SCHEMBL9388097 | 0.74 | SSTR4 (0.43) | KDM4EL3MBTL1SSTR4MCL1SMN1; SMN2 | |
| SCHEMBL3973747 | 0.72 | KMT2A (0.44) | KDM4EL3MBTL1GLABCL2MCL1 | |
| SCHEMBL3979300 | 0.72 | CDK2 (0.36) | SMN1; SMN2HSD17B10MAPTHTTALDH1A1 | |
| SCHEMBL3972624 | 0.70 | POLB (0.55) | SMN1; SMN2MAPTHTTALDH1A1MEN1 | |
| SCHEMBL28242027 | 0.68 | KMO (0.40) | MEN1KMT2ALMNAKMO | |
| SCHEMBL2260028 | 0.68 | NPSR1 (0.41) | KDM4EL3MBTL1MAPTALDH1A1MEN1 | |
| SCHEMBL3975153 | 0.67 | NPC1 (0.38) | L3MBTL1BCL2MCL1SMN1; SMN2MAPT | |
| SCHEMBL3994459 | 0.67 | PCSK9 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050235-A1 | CGRP ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009050235-A1 | CGRP ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |