Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 4/20 | 0.34 |
| ▸ | CA2 | P00918 | 4/20 | 0.34 |
| ▸ | CA4 | P22748 | 4/20 | 0.34 |
| ▸ | CA9 | Q16790 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | TNKS | O95271 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974759 | 0.81 | MAPK9 (0.41) | KCNMA1CA1CA2CA9CCNE1 | |
| SCHEMBL1148724 | 0.78 | MEN1 (0.37) | CA1CA2CA4CA9MEN1 | |
| SCHEMBL3973590 | 0.77 | KCNMA1 (0.38) | KCNMA1MEN1RAB9AKMT2ACCNE1 | |
| SCHEMBL4088457 | 0.77 | KCNMA1 (0.36) | KCNMA1 | |
| SCHEMBL5329381 | 0.77 | TRPA1 (0.40) | KCNMA1TP53 | |
| SCHEMBL1148519 | 0.75 | KCNMA1 (0.48) | KCNMA1CA1CA2CA4CA9 | |
| SCHEMBL1148472 | 0.75 | KCNMA1 (0.48) | KCNMA1CA1CA2CA4CA9 | |
| SCHEMBL5369428 | 0.74 | GABRA1 (0.37) | KCNMA1CA1CA2TP53 | |
| SCHEMBL3974423 | 0.71 | KDM4E (0.36) | KCNMA1KMT2ACDK2 | |
| SCHEMBL1148326 | 0.70 | ALOX5 (0.37) | CA9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054059-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | Synta Pharmaceuticals Corporation (US) | 2009-05-06 | — | — | EP | claimed |
| WO-2008021364-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2008-02-21 | — | — | WO | claimed |