Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.49 |
| ▸ | GPR34 | Q9UPC5 | 4/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 5/20 | 0.44 |
| ▸ | ITGB7 | P26010 | 5/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 2/20 | 0.42 |
| ▸ | ACE | P12821 | 2/20 | 0.42 |
| ▸ | CPA1 | P15085 | 2/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511059 | 0.98 | KIFC1 (0.47) | KIFC1GPR34ITGB1ITGA4ITGB7 | |
| SCHEMBL3973838 | 0.94 | ABCG2 (0.45) | KIFC1GPR34ITGB1ITGA4ITGB7 | |
| SCHEMBL5926509 | 0.90 | ITGA4 (0.44) | GPR34ITGB1ITGA4ITGB7MME | |
| SCHEMBL3976260 | 0.87 | CASP3 (0.42) | PTGER1PTGER4PTGER3PTGER2MME | |
| SCHEMBL5926329 | 0.84 | KIFC1 (0.51) | KIFC1GPR34ITGB1ITGA4ITGB7 | |
| SCHEMBL3978720 | 0.83 | ITGA4 (0.44) | GPR34ITGB1ITGA4ITGB7MME | |
| SCHEMBL6511062 | 0.83 | PTGER1 (0.39) | PTGER1KCNA3 | |
| SCHEMBL5926268 | 0.82 | KIFC1 (0.49) | KIFC1GPR34ITGB1ITGA4ITGB7 | |
| SCHEMBL5927129 | 0.80 | GPR34 (0.57) | KIFC1GPR34ITGB1ITGA4ITGB7 | |
| SCHEMBL5926298 | 0.80 | ITGA4 (0.47) | GPR34ITGB1ITGA4ITGB7ERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501538-B2 | Aryl and heteroaryl compounds, compositions and methods of use | TRANSTECH PHARMA, INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-7501538-B2 | Aryl and heteroaryl compounds, compositions and methods of use | TRANSTECH PHARMA, INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-7501538-B2 | Aryl and heteroaryl compounds, compositions and methods of use | TRANSTECH PHARMA, INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-20050049310-A1 | Aryl and heteroaryl compounds, compositions and methods of use | VTVX HOLDINGS I LLC | 2005-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049310-A1 | Aryl and heteroaryl compounds, compositions and methods of use | EPOR, HBG2, CYP2F1 | KIFC1 4686/4885GPR34 955/4885ITGB1 1520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.