Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | AOC2 | O75106 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725791 | 0.80 | MAOB (0.43) | MAOBMAOAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL27584331 | 0.79 | MAOB (0.42) | MAOBMAOAAOC2DAOMEN1 | |
| SCHEMBL5066069 | 0.78 | SMN1; SMN2 (0.41) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL9943585 | 0.72 | ALDH1A1 (0.62) | ALDH1A1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL12818123 | 0.72 | MAOB (0.51) | MAOBMAOAALDH1A1MEN1KMT2A | |
| SCHEMBL7365892 | 0.71 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2GAARAB9ALMNA | |
| SCHEMBL8069884 | 0.69 | LMNA (0.55) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL13034072 | 0.69 | POLB (0.55) | MAOBALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4646407 | 0.69 | MAPT (0.51) | MAOBMAOAAOC2DAOALDH1A1 | |
| Ethyl Acetate SCHEMBL27956511 | 0.69 | HPGD (0.52) | MAOBMAOAALDH1A1KLK7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057164-A1 | TRIAZOLOTRIAZINES AS KINASE INHIBITORS | Incyte Corporation (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008021781-A1 | TRIAZOLOTRIAZINES AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-02-21 | — | — | WO | disclosed |