Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3739813 | 0.81 | ALDH1A1 (0.44) | SMN1; SMN2CXCL8ALDH1A1HPGDHSD17B10 | |
| SCHEMBL27602026 | 0.80 | KDM4E (0.44) | SMN1; SMN2CXCL8ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3976536 | 0.78 | MAOB (0.41) | SMN1; SMN2ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL6257223 | 0.75 | KDM4E (0.50) | CXCL8KMT2AMEN1KDM4E | |
| SCHEMBL30569631 | 0.72 | KDM4E (0.54) | SMN1; SMN2ALDH1A1HPGDKMT2ALMNA | |
| SCHEMBL10527284 | 0.72 | CXCL8 (0.49) | SMN1; SMN2CXCL8ALDH1A1HPGDHSD17B10 | |
| SCHEMBL247351 | 0.70 | PTGS2 (0.57) | SMN1; SMN2CXCL8ALDH1A1HPGDHSD17B10 | |
| SCHEMBL2320160 | 0.69 | ALDH1A1 (0.54) | SMN1; SMN2CXCL8ALDH1A1HPGDKMT2A | |
| SCHEMBL15197111 | 0.69 | HPGD (0.55) | SMN1; SMN2ALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL7365892 | 0.69 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1HPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318923-A1 | 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318923-A1 | 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle | AVPR1B, AVPR1A, AVPR2 | SMN1; SMN2 2982/4885CXCL8 676/4885ALDH1A1 2628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.