Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.51 |
| ▸ | DRD3 | P35462 | 9/20 | 0.51 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3980647 | 0.92 | CACNA1G (0.55) | DRD2DRD3CACNA1GADRA1AKDM4E | |
| SCHEMBL3980649 | 0.85 | DRD2 (0.64) | DRD2DRD3ADRA1ADRD4MEN1 | |
| SCHEMBL3982337 | 0.84 | KCNH2 (0.53) | DRD2CACNA1GDRD4 | |
| SCHEMBL3976405 | 0.83 | ALDH1A1 (0.49) | DRD2DRD3ADRA1AKDM4EALDH1A1 | |
| SCHEMBL3974517 | 0.80 | HTR1A (0.42) | DRD2DRD3KDM4EALDH1A1TDP1 | |
| SCHEMBL3975562 | 0.78 | HTR1A (0.45) | DRD2DRD3ADRA1AALDH1A1 | |
| SCHEMBL30080718 | 0.76 | HTR1A (0.77) | DRD2DRD3ADRA1AKDM4EALDH1A1 | |
| SCHEMBL946736 | 0.76 | HTR1A (0.77) | DRD2DRD3ADRA1AKDM4EALDH1A1 | |
| SCHEMBL30080722 | 0.76 | HTR1A (0.77) | DRD2DRD3ADRA1AKDM4EALDH1A1 | |
| SCHEMBL3973177 | 0.75 | KCNH2 (0.48) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057138-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | Pierre Fabre Medicament (FR) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008009741-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2008-01-24 | — | — | WO | disclosed |