Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.45 |
| ▸ | HTR7 | P34969 | 7/20 | 0.45 |
| ▸ | HTR1D | P28221 | 4/20 | 0.45 |
| ▸ | HTR2C | P28335 | 4/20 | 0.45 |
| ▸ | HTR2B | P41595 | 4/20 | 0.45 |
| ▸ | HTR5A | P47898 | 4/20 | 0.45 |
| ▸ | HTR6 | P50406 | 4/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3975561 | 0.83 | DRD3 (0.57) | HTR1AHTR2CHTR2AADRA1BDRD2 | |
| SCHEMBL3981786 | 0.79 | SIGMAR1 (0.52) | HTR1AHTR7HTR2CHTR2ADRD2 | |
| SCHEMBL3974517 | 0.79 | HTR1A (0.42) | HTR1AHTR7DRD2DRD3ALDH1A1 | |
| SCHEMBL3976405 | 0.79 | ALDH1A1 (0.49) | HTR7DRD2DRD3ADRA1AGAA | |
| SCHEMBL3200963 | 0.78 | ADRA1B (0.60) | HTR1AHTR7HTR1DHTR2CHTR2B | |
| SCHEMBL3982377 | 0.78 | HTR7 (0.51) | HTR1AHTR7DRD3GAAALDH1A1 | |
| SCHEMBL3980650 | 0.78 | DRD2 (0.51) | DRD2DRD3ADRA1AALDH1A1 | |
| SCHEMBL3977894 | 0.78 | DRD3 (0.58) | HTR1AHTR2CHTR2BHTR2AADRA1B | |
| SCHEMBL3982337 | 0.76 | KCNH2 (0.53) | HTR1AHTR7HTR6HTR2ADRD2 | |
| SCHEMBL3974445 | 0.74 | DRD2 (0.58) | HTR1AHTR2CHTR2AADRA1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057138-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | Pierre Fabre Medicament (FR) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008009741-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2008-01-24 | — | — | WO | disclosed |