Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | DRD3 | P35462 | 4/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974512 | 0.92 | MAPT (0.42) | HTR1AHTR7HTR4KDM4EALDH1A1 | |
| SCHEMBL3982377 | 0.85 | HTR7 (0.51) | HTR1AHTR7ALDH1A1DRD3DRD4 | |
| SCHEMBL3974515 | 0.85 | DRD3 (0.53) | HTR1ADRD2DRD3DRD4CYP2D6 | |
| SCHEMBL3981786 | 0.81 | SIGMAR1 (0.52) | HTR1AHTR7DRD2DRD3 | |
| SCHEMBL3980650 | 0.80 | DRD2 (0.51) | KDM4EALDH1A1TDP1DRD2DRD3 | |
| SCHEMBL3973177 | 0.80 | KCNH2 (0.48) | HTR1AHSD17B10DRD2DRD3 | |
| SCHEMBL3975562 | 0.79 | HTR1A (0.45) | HTR1AHTR7ALDH1A1DRD2DRD3 | |
| SCHEMBL3982372 | 0.78 | HTR7 (0.51) | HTR1AHTR7ALDH1A1DRD3DRD4 | |
| SCHEMBL3196772 | 0.78 | HSD17B10 (0.62) | HTR1AHTR7HSD17B10DRD2DRD3 | |
| SCHEMBL3982337 | 0.78 | KCNH2 (0.53) | HTR1AHTR7DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057138-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | Pierre Fabre Medicament (FR) | 2009-05-13 | — | — | EP | claimed |
| WO-2008009741-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2008-01-24 | — | — | WO | claimed |