Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.42 |
| ▸ | ATP4A | P20648 | 2/20 | 0.42 |
| ▸ | ATP4B | P51164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2961511 | 0.88 | HTR7 (0.43) | CYP1A2CYP2C9IMPDH2MEN1KMT2A | |
| SCHEMBL317502 | 0.77 | MEN1 (0.42) | CYP1A2CYP2C9IMPDH2MEN1KMT2A | |
| SCHEMBL2959702 | 0.75 | KIF11 (0.48) | CYP1A2CYP2C9MEN1KMT2AKDM4E | |
| SCHEMBL317690 | 0.72 | SMN1; SMN2 (0.35) | CYP1A2CYP2C9IMPDH2MEN1KMT2A | |
| SCHEMBL27701196 | 0.70 | IMPDH2 (0.65) | CYP1A2CYP2C9IMPDH2MEN1KMT2A | |
| SCHEMBL704586 | 0.70 | IMPDH2 (0.55) | CYP1A2CYP2C9IMPDH2MEN1KMT2A | |
| SCHEMBL1121782 | 0.68 | CCNB2 (0.44) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL1757795 | 0.68 | HTR2A (0.43) | CYP1A2CYP2C9IMPDH2MAPTALDH1A1 | |
| SCHEMBL12561582 | 0.66 | MAPT (0.55) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL27681973 | 0.65 | PTGS2 (0.59) | IMPDH2MEN1KMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805171-A4 | INDOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF | WYETH CORP (US) | 2009-05-13 | — | — | EP | disclosed |
| EP-1805171-A2 | INDOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF | Athersys, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006034419-A2 | INDOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF | ATHERSYS, INC. (US) | 2006-03-30 | — | — | WO | disclosed |