Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3982377 | 0.92 | HTR7 (0.51) | HTR7MAPTTSHRMEN1ALDH1A1 | |
| SCHEMBL3974512 | 0.86 | MAPT (0.42) | HTR7MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL3982374 | 0.84 | DRD3 (0.52) | HTR7DRD3HTR1ADRD4 | |
| SCHEMBL3981781 | 0.83 | DRD2 (0.50) | HTR7DRD3HTR1A | |
| SCHEMBL3187810 | 0.83 | HTR7 (0.63) | HTR7MAPTTSHRFAAHDRD3 | |
| SCHEMBL3982331 | 0.80 | HTR1A (0.51) | HTR7HTR1ACACNA1G | |
| SCHEMBL3974517 | 0.78 | HTR1A (0.42) | HTR7MAPTALDH1A1DRD3HTR1A | |
| SCHEMBL3978343 | 0.78 | DRD3 (0.52) | HTR7FAAHDRD3HTR1ADRD4 | |
| SCHEMBL3974263 | 0.78 | HTR2A (0.49) | HTR7TSHRMEN1KMT2ADRD3 | |
| SCHEMBL3975348 | 0.77 | DRD2 (0.46) | HTR7DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057138-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | Pierre Fabre Medicament (FR) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008009741-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2008-01-24 | — | — | WO | disclosed |