Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 5/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974517 | 0.92 | HTR1A (0.42) | MAPTHTR7HTR1AHTR4ALDH1A1 | |
| SCHEMBL3982372 | 0.86 | HTR7 (0.51) | MAPTHTR7HTR1AALDH1A1MEN1 | |
| SCHEMBL3974515 | 0.84 | DRD3 (0.53) | HTR1ACYP1A2CYP3A4CYP2D6DRD2 | |
| SCHEMBL3981781 | 0.82 | DRD2 (0.50) | HTR7HTR1APOLBDRD2HTR2A | |
| SCHEMBL3196764 | 0.81 | HTR1A (0.51) | MAPTHTR7HTR1AGFERALDH1A1 | |
| SCHEMBL3980647 | 0.81 | CACNA1G (0.55) | HTR7HTR1AALDH1A1POLBKDM4E | |
| Hydrochloric Acid SCHEMBL3188893 | 0.80 | HTR1A (0.50) | MAPTHTR7HTR1AGFERALDH1A1 | |
| SCHEMBL3982331 | 0.79 | HTR1A (0.51) | HTR7HTR1ADRD2HTR2A | |
| SCHEMBL3974263 | 0.78 | HTR2A (0.49) | HTR7HTR1ADRD2HTR2AMEN1 | |
| SCHEMBL3982377 | 0.77 | HTR7 (0.51) | MAPTHTR7HTR1AALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057138-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | Pierre Fabre Medicament (FR) | 2009-05-13 | — | — | EP | claimed |
| WO-2008009741-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2008-01-24 | — | — | WO | claimed |