Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3989921 | 0.82 | LMNA (0.41) | LMNAMAPK1TSHRMEN1KMT2A | |
| SCHEMBL3984323 | 0.81 | LMNA (0.43) | LMNAMAPK1TSHRMEN1KMT2A | |
| SCHEMBL3983824 | 0.76 | LMNA (0.38) | LMNAMAPK1TSHRMEN1KMT2A | |
| SCHEMBL3989902 | 0.69 | MAPK1 (0.43) | LMNAMAPK1TSHRMEN1KMT2A | |
| SCHEMBL3989567 | 0.68 | LMNA (0.41) | LMNAMAPK1TSHRKMT2AL3MBTL1 | |
| SCHEMBL3985312 | 0.67 | TDP1 (0.47) | TSHRALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL3981251 | 0.67 | P2RX3 (0.40) | LMNAMAPK1TSHRMEN1KMT2A | |
| SCHEMBL14919774 | 0.66 | PDE4D (0.38) | LMNAMAPK1TSHRMEN1KMT2A | |
| SCHEMBL3985878 | 0.66 | PTGDR (0.51) | LMNATSHRKMT2AALDH1A1KDM4E | |
| SCHEMBL3981440 | 0.65 | MEN1 (0.38) | MEN1KMT2AHPGDMAPTPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009060209-A1 | 6,6-FUSED BICYCLIC AROMATIC COMPOUNDS AND THEIR THERAPEUTI USE | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |