Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3987042 | 0.88 | USP2 (0.46) | OPRM1OPRK1KCNH2CYP2D6CYP2C19 | |
| SCHEMBL3987734 | 0.87 | TRPM8 (0.35) | MEN1KMT2ASMN1; SMN2POLBP2RX4 | |
| SCHEMBL3175285 | 0.86 | OPRM1 (0.47) | OPRM1OPRK1KCNH2CYP2D6CYP2C19 | |
| SCHEMBL13395037 | 0.86 | OPRM1 (0.47) | OPRM1OPRK1KCNH2CYP2D6CYP2C19 | |
| SCHEMBL13394988 | 0.86 | OPRM1 (0.47) | OPRM1OPRK1KCNH2CYP2D6CYP2C19 | |
| SCHEMBL3991990 | 0.85 | ACHE (0.41) | OPRM1OPRD1MEN1LMNAKMT2A | |
| SCHEMBL3994605 | 0.85 | USP2 (0.37) | MEN1KMT2ASMN1; SMN2POLBP2RX4 | |
| SCHEMBL3986087 | 0.85 | OPRK1 (0.42) | OPRM1OPRK1KCNH2OPRD1MEN1 | |
| SCHEMBL3987571 | 0.83 | P2RX4 (0.37) | OPRM1OPRD1MEN1KMT2APOLB | |
| SCHEMBL3984341 | 0.83 | OPRM1 (0.43) | OPRM1OPRK1KCNH2OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833826-B1 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-05-27 | — | — | EP | claimed |