Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3987042 | 0.88 | USP2 (0.46) | OPRK1OPRM1KCNH2ALDH1A1TSHR | |
| SCHEMBL4111531 | 0.87 | MAOA (0.37) | OPRM1OPRD1P2RX4ACHEMEN1 | |
| SCHEMBL3987734 | 0.87 | TRPM8 (0.35) | P2RX4ACHETRPM8MEN1NPC1 | |
| SCHEMBL13394990 | 0.86 | OPRM1 (0.42) | OPRK1OPRM1KCNH2OPRD1SIRT1 | |
| SCHEMBL13395040 | 0.86 | OPRM1 (0.42) | OPRK1OPRM1KCNH2OPRD1SIRT1 | |
| SCHEMBL3167429 | 0.86 | OPRM1 (0.42) | OPRK1OPRM1KCNH2OPRD1SIRT1 | |
| SCHEMBL3987430 | 0.86 | OPRK1 (0.42) | OPRK1OPRM1KCNH2SIRT1P2RX4 | |
| SCHEMBL3986089 | 0.85 | OPRM1 (0.42) | OPRK1OPRM1KCNH2LMNAOPRD1 | |
| SCHEMBL3991990 | 0.84 | ACHE (0.41) | OPRM1LMNAOPRD1P2RX4CHRM1 | |
| SCHEMBL3994605 | 0.84 | USP2 (0.37) | ALDH1A1TSHRP2RX4CHRM1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833826-B1 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-05-27 | — | — | EP | claimed |