Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 4/20 | 0.39 |
| ▸ | HTR3A | P46098 | 5/20 | 0.39 |
| ▸ | HTR6 | P50406 | 8/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1004578 | 0.77 | OPRD1 (0.39) | HTR3AKCNH2 | |
| SCHEMBL1004616 | 0.77 | OPRD1 (0.39) | HTR3AKCNH2 | |
| SCHEMBL1004576 | 0.77 | OPRD1 (0.39) | HTR3AKCNH2 | |
| SCHEMBL3984777 | 0.76 | HTR3A (0.40) | NAAAHTR3AHTR6KCNH2HCAR2 | |
| SCHEMBL1004342 | 0.73 | HTR6 (0.58) | NAAAHTR3AHTR6KCNH2HCAR2 | |
| SCHEMBL1006294 | 0.71 | HTR3A (0.66) | HTR3AKCNH2 | |
| SCHEMBL1006296 | 0.71 | HTR3A (0.66) | HTR3AKCNH2 | |
| SCHEMBL4097999 | 0.71 | HTR3A (0.35) | HTR3AHTR6KCNH2 | |
| SCHEMBL1005752 | 0.71 | NAAA (0.49) | NAAAHTR3AKCNH2 | |
| SCHEMBL4293502 | 0.71 | HTR3A (0.61) | NAAAHTR3AHTR6KCNH2HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061460-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | Albany Molecular Research, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008019372-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | ALBANY MOLECULAR RESEARCH, INC. (US) | 2008-02-14 | — | — | WO | disclosed |